慢性酒精依赖患者血清HMGB1、HDAC2与认知功能损害的关系研究  

Study on relationship between HMGB1 and HDAC2 with cognitive functional impairment in patients with chronic alcohol dependence

作　　者：白景林 侯学静 成瑶 刘亚 BAI Jinglin;HOU Xuejing;CHENG Yao;LIU Ya(Fourth Department of Psychiatry,Hengshui Municipal Seventh People′s Hospital/Hengshui Municipal Mental Hospital,Hengshui,Hebei 053000,China;Department of Nuclear Medicine,Hengshui Municipal Seventh People′s Hospital/Hengshui Municipal Mental Hospital,Hengshui,Hebei 053000,China;Fifth Department of Psychiatry,Hengshui Municipal Seventh People′s Hospital/Hengshui Municipal Mental Hospital,Hengshui,Hebei 053000,China)

机构地区：[1]河北省衡水市第七人民医院/衡水市精神病医院精神科四区,河北衡水053000 [2]河北省衡水市第七人民医院/衡水市精神病医院核医学科,河北衡水053000 [3]河北省衡水市第七人民医院/衡水市精神病医院精神科五区,河北衡水053000

出　　处：《检验医学与临床》2025年第9期1231-1235,共5页Laboratory Medicine and Clinic

基　　金：河北省医学科学研究课题计划项目(20221497)。

摘　　要：目的探讨慢性酒精依赖(CAD)患者血清高迁移率族蛋白B1(HMGB1)、组蛋白脱乙酰酶2(HDAC2)与认知功能损害的关系。方法选取2021年2月至2024年2月该院收治的62例CAD并发认知功能损害患者为损害组,选取同期收治的未并发认知功能损害的58例CAD患者为未损害组,选取同期在该院体检的100例体检健康者为对照组。比较各组血清HMGB1、HDAC2水平;采用多因素Logistic回归分析CAD患者发生认知功能损害的影响因素;绘制受试者工作特征(ROC)曲线分析血清HMGB1、HDAC2对CAD患者发生认知功能损害的诊断价值。结果与对照组相比,损害组、未损害组患者血清HMGB1、HDAC2水平均明显升高(P<0.05);与未损害组相比,损害组患者血清HMGB1、HDAC2水平均明显升高(P<0.05)。损害组患者持续饮酒时间、病程均长于未损害组(P<0.05),损害组每日酒精摄入量高于未损害组(P<0.05)。多因素Logistic回归分析结果显示,病程长、每日酒精摄入量大、血清HMGB1水平升高、血清HDAC2水平升高均为CAD患者发生认知功能损害的危险因素(P<0.05)。血清HMGB1、HDAC2诊断CAD患者发生认知功能损害的曲线下面积(AUC)分别为0.836、0.783,二者联合诊断的AUC为0.907,二者联合诊断的AUC明显大于HMGB1(Z=2.523,P=0.012)、HDAC2(Z=3.565,P<0.001)单项诊断的AUC。结论CAD患者血清HMGB1、HDAC2水平均明显上调,均为患者发生认知功能损害的影响因素,二者联合对CAD患者发生认知功能损害具有较高的诊断价值。Objective To investigate the relationship between serum high mobility group protein B1(HMGB1)and histone deacetylase 2(HDAC2)with the cognitive functional impairment in the patients with chronic alcohol dependence(CAD).Methods Sixty-two patients with CAD admitted and treated in this hospital from February 2021 to February 2024 were selected as the impairment group,58 cases of CAD without complicating cognitive functional impairment during the same period were selected as the non-impairment group and 100 healthy individuals undergoing physical examination during the same period were selected as the control group.The levels of serum HMGB1 and HDAC2 were compared among the groups.Multivariate Logistic regression was applied to analyze the influencing factors of cognitive functional impairment in CAD patients.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum HMGB1 and HDAC2 levels for cognitive functional impairment in CAD patients.Results Compared with the control group,the levels of serum HMGB1 and HDAC2 in the impairment group and non-impairment group were significantly increased(P<0.05).Compared with the non-impairment group,the levels of serum HMGB1 and HDAC2 in the impairment group were significantly increased(P<0.05).The duration of drinking and disease duration in the impairment group were significantly longer than those in the non-impairment group(P<0.05),the daily alcohol intake amount in the impairment group was higher than that in the non-impairment group(P<0.05).The multivariate Logistic regression analysis results showed that the long disease duration,large daily alcohol intake,serum HMGB1 level increase and serum HDAC2 level increase were the risk factors for the cognitive functional impairment occurrence in CAD patients(P<0.05).The area under the curve(AUC)of serum HMGB1 and HDAC2 levels for diagnosing the cognitive functional impairment in CAD patients was 0.836 and 0.783,respectively.AUC of the two combination for diagnosing was 0.907,which was signif

关 键 词：慢性酒精依赖 高迁移率族蛋白B1 组蛋白脱乙酰酶2 认知功能损害 蒙特利尔认知评估量表 

分 类 号：R446.11[医药卫生—诊断学] R749.62[医药卫生—临床医学]