BUN、SCr水平与心力衰竭患者经rhBNP联合达格列净治疗后再入院的关系研究  

Study on relationship between BUN and SCr levels with readmission after rhBNP combined with dapagliflozin treatment in patients with heart failure

作　　者：程艳蓉 胡树凤 杨秋艳 CHENG Yanrong;HU Shufeng;YANG Qiuyan(Department of Cardiology,Qinhuangdao Hospital,Third Hospital of Beijing University,Qinhuangdao,Hebei 066000,China)

机构地区：[1]北京大学第三医院秦皇岛医院心内科,河北秦皇岛066000

出　　处：《检验医学与临床》2025年第9期1272-1276,共5页Laboratory Medicine and Clinic

基　　金：河北省秦皇岛市科学技术研究与发展计划项目(202301A226)。

摘　　要：目的探讨血尿素氮(BUN)和血肌酐(SCr)水平与心力衰竭患者经注射用重组人脑利钠肽(rhBNP)联合达格列净治疗后再入院的关系。方法选择2023年1月至2024年4月在该院接受rhBNP联合达格列净治疗的130例心力衰竭患者为观察组,出院后随访5个月,根据患者是否再入院将其分为非再入院组和再入院组。同时选择同期在该院体检的健康志愿者130例为对照组。收集所有研究对象的临床资料,比较观察组与对照组BUN、SCr水平,比较非再入院组和再入院组患者临床资料及BUN、SCr水平,采用多因素Logistic回归分析心力衰竭患者经rhBNP联合达格列净治疗后再入院的影响因素,绘制受试者工作特征(ROC)曲线评估BUN和SCr对心力衰竭患者经rhBNP联合达格列净治疗后再入院的预测价值。结果观察组BUN和SCr水平均明显高于对照组(P<0.05)。再入院组患者BUN、SCr水平均高于非再入院组(P<0.05)。多因素Logistic回归分析结果显示,BUN和SCr水平升高均是心力衰竭患者经rhBNP联合达格列净治疗后再入院的独立危险因素(P<0.05)。BUN、SCr单项及联合预测心力衰竭患者经rhBNP联合达格列净治疗后再入院的AUC分别为0.827、0.832、0.903,联合预测的AUC大于BUN、SCr单项预测的AUC(Z=2.259、1.697,P=0.023、0.031)。结论心力衰竭患者入院时BUN、SCr水平均显著升高,是心力衰竭患者经rhBNP联合达格列净治疗后再入院的独立危险因素,且二者联合对心力衰竭患者经rhBNP联合达格列净治疗后再入院有较高的预测价值。Objective To investigate the relationship between blood urea nitrogen(BUN)and serum creatinine(SCr)levels with readmission after recombinant human brain natriuretic peptide for injection(rhBNP)combined with dapagliflozin treatment in the patients with heart failure.Methods A total of 130 patients with heart failure admitted to this hospital from May 2023 to April 2024 and received the rhBNP combined with dapagliflozin were selected as the observation group.They were followed up for 5 months after discharge and divided into the non-readmission group and readmission group according to whether the patients were readmitted.Meanwhile,130 healthy volunteers who underwent physical examinations in this hospital during the same period were selected as the control group.The clinical data of all patients were collected.The BUN and SCr levels were compared between the observation group and control group.The clinical data and BUN and SCr levels were compared in the non-readmission group and readmission group.The multivariate Logistic regression was used to analyze the influencing factors of readmission after rhBNP combined with dapagliflozin treatment in the patients with heart failure.The receiver operating characteristic(ROC)curve was drawn to evaluate the predictive value of BUN and SCr for readmission after rhBNP combined with dapagliflozin treatment in the patients with heart failure.Results The BUN and SCr levels in the observation group were significantly higher than those in the control group(P<0.05).The BUN and SCr levels in the readmission group were higher than those in the non-readmission group(P<0.05).The results of multivariate Logistic regression analysis showed that the elevated levels of BUN and SCr were the independent risk factors for readmission after rhBNP combined with dapagliflozin treatment in the patients with heart failure(P<0.05).The area under the curve(AUC)of BUN and SCr alone and their combination in prediction readmission after rhBNP combined with dapagliflozin treatment in the patients with hea

关 键 词：急性心力衰竭 再入院 血尿素氮 血肌酐 注射用重组人脑利钠肽 达格列净 

分 类 号：R446.11[医药卫生—诊断学] R541.61[医药卫生—临床医学]