定量磁共振成像技术在帕金森病诊断中的研究进展  

Research progress of quantitative magnetic resonance technique in the diagnosis of Parkinson's disease

作　　者：李明龙 李祥林[2] 刘苗苗 郭蓉 宁洪宇 徐璐梦 刘泉源[1] LI Minglong;LI Xianglin;LIU Miaomiao;GUO Rong;NING Hongyu;XU Lumeng;LIU Quanyuan(Department of Radiology,Affiliated Hospital of Binzhou Medical College,Binzhou 256603,China;School of Medical Imaging Binzhou Medical University,Yantai 264003,China)

机构地区：[1]滨州医学院附属医院放射科,滨州256603 [2]滨州医学院医学影像学院,烟台264003

出　　处：《磁共振成像》2025年第4期108-113,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:62176181);山东省自然科学基金项目(编号:ZR2022MH118)。

摘　　要：帕金森病(Parkinson's disease,PD)是全球中老年常见的第二大神经退行性疾病,在发病初期可能仅表现为手部轻微震颤,所以很容易被忽视,但随着疾病的进展,患者的行走、思维、睡眠等都会受到较大影响,最终因无法活动而长期卧床,生活不能自理。因此,对疾病早期准确诊断有助于更好的治疗,延缓疾病进展,改善预后。定量MRI可以无创地提供PD脑组织内的神经元活动及多种代谢物的改变等丰富的信息,并获得异常的潜在生物学特征。本文将对定量MRI技术在PD中的应用进行综述,旨在帮助临床上对PD的早期诊断、病变评估以及治疗和预后。Parkinson's disease(PD) is the second most common neurological illness among middle-aged and elderly persons worldwide.In the early stages of the disease,it may only manifest as a slight tremor in the hands,making it easy to overlook;however,as the disease progresses,the patient's walking,thinking,sleeping,and so on will be affected,and eventually,he or she will be unable to care for himself or herself due to the inability to move around and become bedridden for an extended period of time.As a result,correct disease identification at an early stage can lead to better therapy,reduce disease progression,and improve prognosis.Quantitative MRI approaches can give non-invasive information on neuronal activity and metabolite changes in PD brain tissue,as well as the underlying biological characteristics of the disorders.In this article,we will look at how quantitative MRI techniques can aid with early PD diagnosis,lesion evaluation,treatment,and prognosis in clinical practice.

关 键 词：帕金森病 磁共振成像 定量技术 化学交换饱和转移成像 神经黑色素成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]