伴中央颞区棘波自限性癫痫功能连接研究进展  

Research progress of Functional Connectivity in self-limited epilepsy with centrotemporal spikes

作　　者：顾晓瑜 张家仁 宋林峰 王俊君 江林 GU Xiaoyu;ZHANG Jiaren;SONG Linfeng;WANG Junjun;JIANG Lin(Department of Radiology,the Third Affiliated Hospital of Zunyi Medical University(the First People's Hospital of Zunyi),Zunyi 563000,China)

机构地区：[1]遵义医科大学第三附属医院(遵义市第一人民医院)放射科,遵义563000

出　　处：《磁共振成像》2025年第4期114-119,138,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82160328)。

摘　　要：伴中央颞区棘波自限性癫痫(self-limited epilepsy with centrotemporal spikes,SeLECTS)是儿童期最常见的年龄依赖性的自限性局灶性癫痫,脑电图特征性表现为发作间期中央-颞区(即Rolandic区)棘波。尽管SeLECTS被认为是自限性的,但研究发现,缓解后部分患儿仍有语言、阅读、视觉空间、执行功能和注意力等认知障碍。这些障碍可能与大脑功能连接(functional connectivity,FC)的异常有关,且不同脑区的FC可能同时表现出增加和降低的矛盾情况。本文简要介绍了FC常见的研究方法,对这些方法的优势及不足进行总结,同时总结了近年来FC在SeLECTS中的研究进展,探索FC作为生物标志物在预测认知和癫痫发作结果方面的潜力。Self-limited epilepsy with centrotemporal spikes(SeLECTS) is the most common age-dependent,self-limited focal epilepsy of childhood,characterised by interictal centrotemporal(Rolandic) spikes on the EEG.Although SeLECTS is considered self-limiting,some children have cognitive deficits in language,reading,visuospatial,executive function and attention.These deficits may be related to abnormalities in functional connectivity(FC),which can be paradoxically increased and decreased in different brain regions at the same time.This paper briefly introduces common functional connectivity research methods,summarises the strengths and weaknesses of these methods,and also summarises the research progress of FC in SeLECTS over the past years,with the aim of exploring the potential of FC as a biomarker for predicting cognitive and seizure outcomes.

关 键 词：伴中央颞区棘波自限性癫痫 Rolandic癫痫 磁共振成像 功能磁共振成像 脑网络 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.1[医药卫生—诊断学]