针刺治疗轻度认知障碍的神经影像学研究进展  

Neuroimaging advances in acupuncture for mild cognitive impairment

作　　者：王艺璇 李淑雅 刘烜利 么雨彤 蔺建文 蔡鸣[3] 李坤成[4] 赵亚维 韩芳 WANG Yixuan;LI Shuya;LIU Xuanli;YAO Yutong;LIN Jianwen;CAI Ming;LI Kuncheng;ZHAO Yawei;HAN Fang(Department of PET/CT Medical Center,Zhongshan Hospital Affiliated to Dalian University,Dalian 116001,China;Department of Psychiatry,Dalian University of Technology Affiliated Central Hospital,Dalian 116001,China;Department of Neurology,Zhongshan Hospital Affiliated to Dalian University,Dalian 116001,China;Department of Radiology and Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Imaging,Xinhua Hospital Affiliated to Dalian University,Dalian Key Laboratory of Functional and Molecular Imaging,Dalian 116001,China)

机构地区：[1]大连大学附属中山医院PET/CT医学中心,大连116001 [2]大连理工大学附属中心医院精神心理科,大连116001 [3]大连大学附属中山医院神经内科,大连116001 [4]首都医科大学宣武医院放射与核医学科,北京100053 [5]大连大学附属新华医院影像科,大连市功能与分子影像重点实验室,大连116001

出　　处：《磁共振成像》2025年第4期120-125,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：科技部科技创新2030“脑科学与类脑研究”重大项目(编号:2022ZD0211800);辽宁省科技计划技术攻关项目(编号:2024011209-JH/1026);大连市中医药科学研究计划项目(编号:23Z12012)。

摘　　要：轻度认知障碍(mild cognitive impairment,MCI)是指记忆力或其他认知功能进行性减退,属阿尔茨海默病的早期阶段,是早诊与防治的关键窗口期,尚无药物根治。针刺治疗以适应证广、见效快、操作简便等优点广泛应用,但其临床治疗机制尚不明确。近年来随着多模态成像技术的快速发展以及针刺治疗MCI神经影像学研究的持续深入,基于结构功能与分子影像等客观信息可精准评估MCI大脑的针刺治疗效果,便于临床早期/超早期治疗与干预,为疾病发生机制探讨提供客观佐证。现就国内外针刺治疗MCI患者神经影像学技术研究进展予以综述,以期为进一步揭示针刺对MCI的治疗作用机制提供新思路,为临床精准诊疗提供新视角。Mild cognitive impairment(MCI) refers to the progressive decline of memory or other cognitive functions,which belongs to the early stage of Alzheimer's disease and is the key window of early diagnosis,prevention and treatment,and there is no drug radical cure.Acupuncture is widely used for its wide indications,quick response and simple operation,but its clinical treatment mechanism is still unclear.In recent years,with the rapid development of multimodal imaging technology and the continuous deepening of neuroimaging research on acupuncture treatment of MCI,the acupuncture treatment effect of MCI brain is accurately evaluated based on objective information such as structure,function and molecular imaging.It's convenient for early/ultra-early clinical treatment and intervention,provides objective evidence for the discussion of disease pathogenesis.This paper reviews the research progress of brain functional imaging technology in treating MCI patients with acupuncture,in order to provide new ideas for further revealing the mechanism of acupuncture on MCI diseases and a new perspective for clinical accurate diagnosis and treatment.

关 键 词：轻度认知障碍 针刺 神经影像学 功能磁共振成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749[医药卫生—诊断学]