抑郁症多模态磁共振脑成像与炎性标志物的相关性研究进展  

Research progress on the correlation between multimodal MRI brain imaging and inflammatory markers in depression

作　　者：凌琰鑫 汪雨婷 邓杰 杨虹莉 程燕 邱丽华 LING Yanxin;WANG Yuting;DENG Jie;YANG Hongli;CHENG Yan;QIU Lihua(Department of Radiology,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Medical Imaging Center of Yibin Second People's Hospital,Yibin 644000,China;Radiology Department of Yibin Fourth People's Hospital,Yibin 644000,China;Yibin Second People's Hospital·Clinical Medicine Research and Transformation Center of West China Hospital,Sichuan University,Big Data Research Center for Neuroimaging,Yibin 644000,China)

机构地区：[1]西南医科大学附属医院放射科,泸州646000 [2]宜宾市第二人民医院医学影像中心,宜宾644000 [3]宜宾市第四人民医院放射科,宜宾644000 [4]宜宾市第二人民医院·四川大学华西医院宜宾医院临床医学研究与转化中心,神经影像大数据研究中心,宜宾644000

出　　处：《磁共振成像》2025年第4期126-131,144,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82372080);四川省科技计划项目(编号:2018JY0666);四川省卫生健康委员会医学科技资助项目(编号:24WSXT071);四川省卫生健康委项目(编号:23LCYJ021);功能与分子影像四川省重点实验室开放课题(编号:SCU-HM-2021001);宜宾市科学技术计划项目(编号:2024SF001)。

摘　　要：抑郁症发病率、自杀率逐年攀升,已成为一个严峻的全球公共卫生问题。近年来较多研究显示,外周血炎性标志物与抑郁症的病理生理过程关系紧密。炎性标志物与抑郁症的相关性可通过多模态磁共振成像进行表征,进一步加深了对抑郁症进展、治疗靶点选择以及预后评估的探索。本文简要综述近年来炎性标志物与多模态磁共振成像的影像学表征在抑郁症的相关性研究及潜在不足,旨在为今后的研究提供方向。The incidence rate of depression and suicide rate have been rising year by year,and this has become a serious global public health issue.In recent years,some studies have shown that peripheral blood inflammatory markers are closely related to the pathophysiological processes of depression.The correlation between inflammatory markers and depression can be characterized by multimodal MRI,which further deepens the exploration into the progression of depression,the selection of treatment targets,and prognosis assessment.This review briefly summarizes recent research on the correlation between inflammatory markers and the imaging characteristics of multimodal MRI in depression,as well as potential limitations,aiming to provide direction for future studies.

关 键 词：抑郁症 炎性标志物 多模态磁共振成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.41[医药卫生—诊断学]