克罗恩病伴负面情绪患者的大脑多模态影像技术研究进展  

Progress on multimodal imaging technology in the brains of Crohn's disease patients with negative emotions

作　　者：余丽 杨玲[2,3] 吴欣妍 唐开强 张玲琴 李康 YU Li;YANG Ling;WU Xinyan;TANG Kaiqiang;ZHANG Lingqin;LI Kang(Chongqing Medical University,Chongqing 400016,China;Department of Radiology,Chongqing General Hospital,Chongqing University,Chongqing 401147,China;Department of Radiology,Chongqing General Hospital,Chongqing 401147,China;North Sichuan Medical Colledge,Nanchong 637100,China)

机构地区：[1]重庆医科大学,重庆400016 [2]重庆大学附属人民医院放射科,重庆401147 [3]重庆市人民医院放射科,重庆401147 [4]川北医学院,南充637100

出　　处：《磁共振成像》2025年第4期132-138,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：重庆市科技创新重大研发项目(编号:CSTB2024TIAD-STX0045)。

摘　　要：克罗恩病(Crohn's disease,CD)患者常伴焦虑、抑郁等负面情绪,这不仅可能影响患者的心理健康,还可能加剧疾病进程,降低其生活质量。目前,临床对于CD患者常伴负面情绪的认知较低,一般的抗炎治疗不能有效缓解患者的这些症状,而且对其诊断的方法局限且具有主观性,所以找到客观的评估方法、指导临床诊疗成为了问题的关键。越来越多的研究表明CD患者负面情绪的产生可能与特定脑区结构、功能变化密切相关。目前,多模态影像技术,如结构MRI、功能MRI和近红外光谱成像,已广泛运用于脑功能、结构变化研究,并说明了一定的临床价值。本文综述了近年来基于多模态影像技术找到的与CD患者焦虑、抑郁等负面情绪相关的大脑结构、功能变化影像结果,为未来CD患者合并负面情绪的评估和治疗提供影像学依据。Patients with Crohn's disease(CD) often experience negative emotions such as anxiety and depression,which not only potentially compromise their mental health but also aggravate the disease progression and diminish their quality of life.Currently,clinical recognition of the negative emotions commonly associated with CD is limited.Standard anti-inflammatory treatments are ineffective in alleviating these symptoms,and the diagnostic methods available are subjective and restricted.Therefore,finding objective assessment methods to guide clinical diagnosis and treatment has become a critical issue.An increasing number of studies suggest that the development of negative emotions in CD patients is closely linked to structural and functional changes in specific brain regions.Currently,multimodal imaging techniques,such as structural magnetic resonance imaging,functional magnetic resonance imaging,and near-infrared spectroscopy,have been widely applied in the study of brain function and structural changes,demonstrating significant clinical value.This review will summarize the recent findings based on multimodal imaging techniques that have identified brain structural and functional changes associated with negative emotions such as anxiety and depression in CD patients.These findings provide neuroimaging-based evidence for future assessments and treatments of CD patients with comorbid negative emotions.

关 键 词：克罗恩病 焦虑 抑郁 磁共振成像 结构磁共振成像 功能磁共振成像 近红外光谱成像技术 

分 类 号：R445.2[医药卫生—影像医学与核医学] R574[医药卫生—诊断学]