代谢功能障碍相关脂肪性肝病的脑MRI研究进展  

Advances in brain MRI research of metabolic dysfunction-associated steatotic liver disease

作　　者：范文晓 王永祥 FAN Wenxiao;WANG Yongxiang(School of Nursing,Shandong First Medical University(Shandong Academy of Medical Sciences),Taian 271016,China;Department of Neurology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)护理学院,泰安271016 [2]山东第一医科大学附属省立医院神经内科,济南250021

出　　处：《磁共振成像》2025年第4期151-154,167,共5页Chinese Journal of Magnetic Resonance Imaging

摘　　要：作为全身代谢性疾病的肝脏表现,代谢功能障碍相关脂肪性肝病(metabolic dysfunction-associated steatotic liver disease,MASLD)已成为最常见的慢性肝病。既往研究表明MASLD可能与痴呆和认知功能损害相关。通过MRI观察MASLD患者脑结构和功能异常,能够更好地探索MASLD认知功能损害的病理机制。本文就MASLD患者脑结构、脑功能和脑灌注的MRI研究进展进行综述,为探索MASLD与痴呆相关机制以及优化MASLD患者认知功能损害治疗策略提供神经影像学基础。As a hepatic manifestation of systemic metabolic disorders,metabolic dysfunction-associated steatotic liver disease(MASLD) has emerged as the most prevalent chronic liver disease.Previous studies have shown that MASLD may be associated with dementia and cognitive impairment.The brain structure and function abnormalities in MASLD patients can be observed by MRI to better explore the pathological mechanism of cognitive impairment in MASLD.This article reviews the advances in MRI studies on brain structure,function and cerebral perfusion in patients with MASLD,providing a neuroimaging foundation for exploring the mechanisms linking MASLD to dementia and optimizing therapeutic strategies for cognitive impairment in MASLD patients.

关 键 词：代谢功能障碍相关脂肪性肝病 代谢功能障碍相关脂肪性肝炎 磁共振成像 脑结构 扩散张量成像 静息态功能磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R575[医药卫生—诊断学] R745.1[医药卫生—临床医学]