功能磁共振成像技术在颈动脉狭窄相关认知障碍的研究进展  

Advances in functional magnetic resonance imaging in carotid artery stenosis and associated cognitive impairment

作　　者：高佳雯 郑宁[2,3] 邵硕[2,3] GAO Jiawen;ZHENG Ning;SHAO Shuo(School of Medical Imaging,Shandong Second Medical University,Weifang 261053,China;Department of Radiology,Jining First People's Hospital,Jining 272000,China;Cognitive Disorders Specialized Disease Center of Jining First People's Hospital,Jining 272000,China)

机构地区：[1]山东第二医科大学医学影像学院,潍坊261053 [2]济宁市第一人民医院放射科,济宁272000 [3]济宁市第一人民医院认知障碍专病中心,济宁272000

出　　处：《磁共振成像》2025年第4期161-167,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：济宁市重点研发计划项目(编号:2023YXNS117)。

摘　　要：颈动脉狭窄(carotid artery stenosis,CAS)是一种常见的血管疾病,它不仅与缺血性卒中的发生密切相关,还与认知功能障碍有显著关联性,对患者的生活质量造成了严重影响。无症状颈动脉狭窄(asymptomatic carotid stenosis,ACS)是指尚未发生短暂性脑缺血发作(transient ischemic attack,TIA)、缺血性卒中或痴呆的颈动脉疾病。即使在无症状的CAS患者中,也可导致显著的认知功能障碍。为了防止向痴呆进一步发展,迫切需要研究CAS与认知之间的关系。随着现代脑成像技术的发展,功能磁共振成像(functional magnetic resonance imaging,fMRI)技术能够敏感检测出脑组织血流灌注、结构与功能的异常,为阐明CAS相关认知障碍机制提供了关键影像学证据。本文旨在综述近年来fMRI技术在CAS相关认知障碍的最新研究进展,以期待为CAS的评估和诊疗提供新思路。Carotid artery stenosis(CAS) is a common vascular disease,which is not only closely related to the occurrence of ischaemic stroke,but also significantly associated with cognitive dysfunction,which seriously affects the quality of life of patients.Asymptomatic carotid stenosis(ACS) is carotid artery disease that has not yet resulted in a transient ischemic attack(TIA),ischemic stroke,or dementia.Even in asymptomatic patients with CAS,it can lead to significant cognitive dysfunction.In order to prevent further progression towards dementia,there is an urgent need to study the relationship between CAS and cognition.With the development of modern brain imaging technology,functional magnetic resonance imaging(fMRI) technology is able to sensitively detect abnormalities in brain tissue perfusion,structure and function,provided key imaging evidence to elucidate the mechanisms of CAS-related cognitive impairment.The purpose of this article is to review the latest research progress of fMRI technology in carotid artery stenosis and related cognitive impairment in recent years,in anticipation of providing new ideas for the assessment and diagnosis of CAS.

关 键 词：颈动脉狭窄 认知功能障碍 磁共振成像 脑功能 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743[医药卫生—诊断学]