PCASL成像技术伪影及其临床研究进展  

Research progress of PCASL imaging technology artifact and its clinic

作　　者：李中欣 贺业新[2] LI Zhongxin;HE Yexin(Department of Medical Imaging,Shanxi Medical University,Taiyuan 030001,China;Department of Radiology,Shanxi Provincial People's Hospital,Fifth Clinical College of Shanxi Medical University,Taiyuan 030012,China)

机构地区：[1]山西医科大学医学影像学院,太原030001 [2]山西医科大学第五临床学院/山西省人民医院放射科,太原030012

出　　处：《磁共振成像》2025年第4期228-234,共7页Chinese Journal of Magnetic Resonance Imaging

摘　　要：动脉自旋标记(arterial spin labeling,ASL)技术是一种无创的磁共振灌注成像技术,它利用流动血液中磁性标记的水作为内源性示踪剂来评估脑血流量(cerebral blood flow,CBF)。目前在脑血管病、脑肿瘤、癫痫及神经退行性疾病等方面展现出了独特的临床价值。随着技术的不断发展,根据脉冲方式的不同可分为四类,目前临床最常采用的是准连续式ASL(pseudocontinuous ASL,PCASL)技术。虽然PCASL技术在临床应用中表现出了巨大的潜力,但在成像过程中仍然面临着伪影产生的问题。这些伪影可能出现在成像的各个阶段,主要可以分为在标记期间、动脉传输期间、读出期间三类,伪影的成因和表现也很复杂。因此,深入研究PCASL技术的伪影对于进一步提高PCASL技术在临床应用中的准确性和可靠性具有重要意义。本文就PCASL技术伪影的表现特点、产生原因、补救措施、部分伪影潜在的临床价值等方面进行综述,以期通挖掘其临床价值,提升PCASL在神经影像领域的实用性和可靠性。Arterial spin labeling(ASL) is a non-invasive magnetic resonance perfusion imaging technique that uses magnetically labeled water in flowing blood as an endogenous tracer to assess cerebral blood flow(CBF).At present,it has demonstrated unique clinical value in cerebrovascular diseases,brain tumors,epilepsy and neurodegenerative diseases.With the continuous development of technology,it can be divided into four categories according to different pulse methods,and the most commonly used technology in clinical practice is pseudocontinuous ASL(PCASL).Although PCASL technology has shown great potential in clinical applications,it still faces the problem of artifact generation during imaging.These artifacts may occur at all stages of imaging,and can be divided into three main categories:during labeling,during arterial transmission,and during readout,and the causes and manifestations of artifacts are complex.Therefore,it is of great significance to further improve the accuracy and reliability of PCASL technology in clinical applications.This article reviews the performance characteristics,causes,remedial measures,and potential clinical value of PCASL technical artifacts,in order to explore its clinical value and improve the practicability and reliability of PCASL in the field of neuroimaging.

关 键 词：磁共振成像 动脉自旋标记 伪影 准连续式动脉自旋标记 动脉传输时间 标记后延迟时间 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.81[医药卫生—诊断学]