金属催化下构建氮杂环骨架的双环化反应研究  

Study on the Bicyclization Reaction for Construction of Nitrogen Heterocyclic Skeleton under Metal Catalysis

作　　者：范威 Fan Wei(Science and Technology Office,Chuzhou City Vocation College,Chuzhou,Anhui 239000,China)

机构地区：[1]滁州城市职业学院科技处,安徽滁州239000

出　　处：《伊犁师范大学学报(自然科学版)》2025年第1期72-77,共6页Journal of Yili Normal University(Natural Science Edition)

基　　金：安徽省高校中青年教师培养行动项目(YQZD2024077);滁州城市职业学院平台项目(2023zkzd05);滁州城市职业学院校级科研项目(2024xszz01)。

摘　　要：以Benzazepril、Physostigmine、Dehaloperophoramidine为代表的活性分子都含有氮杂环骨架,该类衍生物具有很好的生物和药理活性.探索绿色高效的氮杂环骨架构建新方法,一直是化学合成的热点话题.为此,对近年来金属催化下构建氮杂环骨架的双环化反应取得的研究成果进行了梳理和总结,以期为后续该类骨架的高效构建提供启发.Active molecules represented by Benzazepril,Physostigmine and Dehaloperophoramidine all contain nitrogen heterocyclic skeletons.Such derivatives have good biological and pharmacological activities.Exploring new methods for constructing green and efficient nitrogen heterocyclic frameworks has always been a hot topic in chemical synthesis.Therefore,the research results on the bicyclization reaction of constructing nitrogen heterocyclic frameworks under metal catalysis in recent years were summarized and organized,in order to provide inspiration for the efficient construction of such frameworks in the future.

关 键 词：金属催化 氮杂环 双环化 

分 类 号：O621.3[理学—有机化学]