长链非编码RNA在特应性皮炎中的研究进展  

Research progress of long noncoding RNA in atopic dermatitis

作　　者：刘鑫[1,2] 蔡新颖 Liu Xin;Cai Xinying(Department of Dermatology,the First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230032,China;Institute of Dermatology,Anhui Medical University,Hefei,Anhui 230032,China)

机构地区：[1]安徽医科大学第一附属医院皮肤性病科,合肥230032 [2]安徽医科大学皮肤病研究所,合肥230032

出　　处：《中华医学遗传学杂志》2025年第2期244-248,共5页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金(82203920)。

摘　　要：长链非编码RNA(lncRNA)是一类长度大于200个核苷酸且不具有编码蛋白质能力的RNA。特应性皮炎(AD)是一种常见慢性炎症性皮肤病,遗传易感、皮肤屏障受损和免疫失衡在其发病中起重要作用。研究表明,lncRNA异常表达在多种人类疾病的发生和发展中扮演着关键角色,多种lncRNA在AD患者中表达异常,并参与AD的发生、发展。笔者拟对lncRNA在AD的研究进展进行综述,旨在为AD发病机制和治疗提供更多参考。Long noncoding RNA(lncRNA)is a type of RNA that is longer than 200 nucleotides and does not encode proteins.Atopic dermatitis(AD)is a common chronic inflammatory skin disease.Genetic susceptibility,damaged skin barrier and immune imbalance play important roles in its pathogenesis.Studies have shown that abnormal expression of lncRNA plays an important role in the development of many human diseases.In recent years,it has been found that various lncRNAs are abnormally expressed in AD patients and are involved in the development of AD.This paper reviews the research progress of lncRNAs in AD,aiming to provide more reference for the pathogenesis and treatment of AD.

关 键 词：RNA 长链非编码 皮炎 特应性 皮肤屏障 免疫失衡 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]