肠道菌群调控提升免疫检查点抑制剂抗肿瘤效果研究进展  

Advance in gut microbiota regulation to enhance the anti-tumor efficacy of immune checkpoint inhibitors

作　　者：陈丽[1,2] 杨坤[1,2] 胥海婷 刘嘎 肖波 CHEN Li;YANG Kun;XU Hai-ting;LIU Ga;XIAO Bo(State Key Laboratory of Resource Insects,Southwest University,Chongqing 400715,China;Department of Biotechnology,College of Sericulture,Textile,and Biomass Sciences,Southwest University,Chongqing 400715,China;Department of Pharmacy,Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Academy of Medical Sciences&Sichuan Provincial People′s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China)

机构地区：[1]西南大学资源昆虫高效养殖与利用全国重点实验室,重庆400715 [2]西南大学蚕桑纺织与生物质科学学院生物技术系,重庆400715 [3]电子科技大学医学院,四川省医学科学院、四川省人民医院,个体化药物治疗四川省重点实验室,药学部,四川成都610054

出　　处：《药学学报》2025年第4期903-918,共16页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82472132,82360110)。

摘　　要：免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)是癌症免疫治疗的重要药物,但绝大部分患者对ICIs存在耐药性或短期反应。肠道菌群作为重要的免疫调节器,已被证明在增强ICIs疗效中起关键作用。研究表明,通过粪菌移植或特定菌株移植,可直接改变肠道菌群的组成,进而提升ICIs免疫治疗效果。此外,饮食干预、益生元和后生元等手段也能通过调控肠道菌群提高ICIs的抗肿瘤效果。尽管如此,如何优化菌群/株的选择和治疗方案仍需进一步探索。本文综述了肠道菌群调控在ICIs治疗癌症中的关键作用及其应用,为提升肿瘤免疫治疗效果提供了实践基础和理论依据。Immune checkpoint inhibitors(ICIs)have emerged as critical agents in cancer immunotherapy;however,their resistance and limited response in most patients pose significant challenge.The gut microbiota,as a pivotal immune regulator,has been increasingly recognized for its role in enhancing the therapeutic efficacy of ICIs.Studies demonstrate that fecal microbiota transplantation or transplantation of specific bacterial strains can directly reshape the gut microbiota composition,thereby improving ICI therapeutic outcomes.Furthermore,dietary interventions,prebiotics,and postbiotics have shown potential in augmenting the anti-tumor effects of ICIs through gut microbiota modulation.Despite these promising findings,further investigations are required to optimize microbiota-based strategies and therapeutic protocols.This review highlights the critical role of gut microbiota modulation in ICI-based cancer therapy and explores its clinical applications,offering both practical insights and theoretical foundations for improving immunotherapy outcomes against various cancers.

关 键 词：癌症 免疫治疗 免疫检查点抑制剂 肠道菌群 粪菌移植 

分 类 号：R966[医药卫生—药理学]