金属配位化学在中药新药研发中的应用及研究进展  

Application and research progress of metal coordination chemistry in the research and development of new drugs of traditional Chinese medicine

作　　者：徐振娜 丁浩冉 徐子航 吴梦茹 朱叶寒 周梦娇 李遇伯[1] 樊慧蓉[2] 姚雅琦 XU Zhen-na;DING Hao-ran;XU Zi-hang;WU Meng-ru;ZHU Ye-han;ZHOU Meng-jiao;LI Yu-bo;FAN Hui-rong;YAO Ya-qi(School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Institute of Radiation Medicine,Chinese Academy of Medical Sciences,Tianjin 300192,China;College of Pharmacy,Shandong Xiandai University,Jinan 250154,China)

机构地区：[1]天津中医药大学中药学院,天津301617 [2]中国医学科学院放射医学研究所,天津300192 [3]山东现代学院药学院,山东济南250154

出　　处：《药学学报》2025年第4期919-928,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82204760)。

摘　　要：我国中药资源丰富,许多有效成分中含有易与金属离子发生配位反应的官能团,如氨基、羧基、羟基等。这些官能团能够与金属离子络合,产生新的化合物。这些中药金属配合物与对应单体相比,往往表现出独特的性质和功能,为新药开发提供了新路径。本综述从中药金属配合物的形成原理及常见配位金属离子出发,将中药中的有效成分大致分为蒽醌、生物碱、黄酮、香豆素、氨基酸类、多糖类化合物,对其与金属形成的配合物进行综述,以期为中药新药的发现和开发提供新的思路,为中药现代化和国际化提供科学依据。There are abundant resources of traditional Chinese medicine in China,and it is found that the effective components of traditional Chinese medicine contain functional groups that are easy to coordinate with metal ions,such as amino,carboxyl and hydroxyl,which can complex with transition metal ions to derive new compounds.These traditional Chinese medicine metal complexes often exhibit unique properties and functions compared with their corresponding monomers,providing a new path for new drug development.Based on the formation principle of metal complexes with traditional Chinese medicine and the common coordination metal ions,in this review,the effective components in traditional Chinese medicine are roughly divided into anthraquinone,alkaloid,flavone,coumarin,amino acids and polysaccharide compounds,so as to provide new ideas for the discovery of new traditional Chinese medicine,and provide scientific basis for the modernization and internationalization of traditional Chinese medicine.

关 键 词：中药 天然产物 中药配伍 金属配合物 生物活性 新药研发 

分 类 号：R943[医药卫生—药剂学]