中药挥发油治疗脑胶质瘤的作用机制及其纳米制剂的研究进展  

Researches on the anti-glioma mechanism of volatile oil from traditional Chinese medicines and nano-preparation applications

作　　者：王佳华 汪莲芳 柯刚 胡鹏翼[1,2] 伍丽 郑琴 张继稳 WANG Jia-hua;WANG Lian-fang;KE Gang;HU Peng-yi;WU Li;ZHENG Qin;ZHANG Ji-wen(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Jiangxi Provincial Key Laboratory of Improvement and Innovation of Traditional Chinese Medicine,Nanchang 330004,China;Luzhou People′s Hospital,Luzhou 646000,China;Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201210,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004 [2]中药改良创新江西省重点实验室,江西南昌330004 [3]泸州市人民医院,四川泸州646000 [4]中国科学院上海药物研究所,上海201210

出　　处：《药学学报》2025年第4期929-938,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金项目(82060719)。

摘　　要：脑胶质瘤是最常见的中枢神经系统原发性肿瘤,其一线治疗药物受血脑屏障阻碍,在肿瘤部位难以达到有效剂量。中药挥发油具有高脂溶性、易穿过血脑屏障等优点,表现出良好的抗脑胶质瘤作用。引经中药具有引药上行功效,一些挥发油成分可通过促进化药入脑、抑制脑内药物外排、协同化药治疗等方式提高抗脑胶质瘤作用。但挥发油稳定性差,纳米制剂如脂质体、纳米粒、自组装前药递药系统等可改善其稳定性,并通过注射给药方式发挥治疗脑胶质瘤效果,为挥发油治疗脑胶质瘤提供良好的应用前景。本文综述了中药挥发油及其主要成分抗脑胶质瘤的作用机制,以及挥发油联用化疗药物及其纳米药物递送系统治疗脑胶质瘤的研究进展,以期为中药挥发油在脑胶质瘤治疗中的应用提供参考。Gliomas are the most common primary tumors in the central nervous system.However,the efficacy of first-line treatments for glioma is hindered by the blood brain barrier(BBB),making it difficult to reach an effective dose at the tumor site.The volatile oil from traditional Chinese medicine have the advantages of high fat solubility and ability to penetrate the blood brain barrier,has demonstrated promising inhibitory effects on glioma.The volatile oil components of traditional Chinese medicine can improve the anti-glioma efficacy by promoting the entry of chemotherapeutic drugs into the brain,inhibiting the exocytosis of drugs within the brain and synergizing with chemical drug therapy.However,the stability of volatile oil is poor,nano-formulations including liposomes,nanoparticles,and self-assembled prodrug delivery systems,can improve their stability and exert the therapeutic efficacy.As an effective drug for the treatment of glioma,volatile oil from traditional Chinese medicine shows good prospects for application.This review summarizes the mechanisms of action of volatile oil from traditional Chinese medicine and their main components against glioma,and the research progress of volatile oil combined with chemotherapeutic drugs or designed as nano-drug delivery systems for glioma therapy,with a view to providing reference for the application of volatile oil from traditional Chinese medicine in the treatment of glioma.

关 键 词：中药挥发油 脑胶质瘤 作用机制 联合给药 纳米制剂 

分 类 号：R943[医药卫生—药剂学]