山茱萸叶中1个新的倍半萜及其潜在神经保护活性  

A new sesquiterpene from the leaves of Cornus officinalis and their potential neuroprotective activities

作　　者：张靖柯 朱登辉 李孟[1,2] 解双双 曾梦楠 郑晓珂[1,2] 冯卫生 ZHANG Jing-ke;ZHU Deng-hui;LI Meng;XIE Shuang-shuang;ZENG Meng-nan;ZHENG Xiao-ke;FENG Wei-sheng(Henan University of Chinese Medicine,Zhengzhou 450046,China;The Engineering and Technology Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南省中药开发工程技术研究中心,河南郑州450046

出　　处：《药学学报》2025年第4期1041-1045,共5页Acta Pharmaceutica Sinica

基　　金：中央引导地方科技发展专项资助项目(豫财科[2016]149);河南省高等学校重点科研项目(24A360017)。

摘　　要：利用现代柱色谱技术,如大孔吸附树脂、硅胶、凝胶及半制备液相等,从山茱萸传统非药用部位山茱萸叶50%丙酮提取物中分离得到5个倍半萜类成分。通过现代波谱学技术以及电子圆二色谱(ECD)技术鉴定了化合物的结构,分别为山茱萸新萜苷A(1)、cornucadinoside B(2)、lacinilene C(3)、3,12-dihydroxycadalene(4)、cornucadinoside C(5)。其中,化合物1为新化合物,化合物2~5为首次从山茱萸叶中分离得到,并且化合物2和3具有潜在神经保护活性。Five sesquiterpenoids were isolated from a 50%acetone extract of Cornus officinalis leaves,a traditional non-medicinal part of Cornus officinalis,using modern column chromatographic techniques such as macroporous adsorbent resins colum,silica gel colum,chromatography gel colum and semi-preparative liquid chromatography techniques.Their structures were identified by modern wave spectroscopy techniques and electronic circular dichroism(ECD)and assigned as cornurtone A(1),cornucadinoside B(2),lacinilene C(3),3,12-dihydroxycadalene(4),cornucadinoside C(5).Compound 1 was new compound and compounds 2-5 were first isolated from leaves of Cornus officinalis.Compounds 2 and 3 had potential neuroprotective activities.

关 键 词：山茱萸叶 倍半萜 结构鉴定 神经保护 

分 类 号：R284[医药卫生—中药学]