宽跗陇马陆中2个新含氮化合物的分离鉴定  

Isolation and identification of two new nitrogen-containing compounds from Kronopolites svenhedini(Verhoeff)

作　　者：李淇 袁苑楠 晏永明 程永现[1,2] LI Qi;YUAN Yuan-nan;YAN Yong-ming;CHENG Yong-xian(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Guangdong Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics,Institute for Inheritance-Based Innovation of Chinese Medicine,School of Pharmacy,Shenzhen University Medical School,Shenzhen University,Shenzhen 518060,China)

机构地区：[1]成都中医药大学药学院,四川成都611137 [2]深圳大学医学部药学院,中医药守正创新研究院,广东省中药有效成分与肠道微生物组学重点实验室,广东深圳518060

出　　处：《药学学报》2025年第4期1069-1073,共5页Acta Pharmaceutica Sinica

基　　金：深圳市高层次人才团队项目(KQTD20210811090219022);国家自然科学基金项目(82322071)。

摘　　要：利用各种色谱技术从宽跗陇马陆[Kronopolites svenhedini (Verhoeff)]中分离得到了14个化合物。结合波谱学方法和文献鉴定其结构,分别为kronoponit A (1)、kronoponit B (2)、neoechinulin A (3)、2-(1,1-dimethyl-2-propen-1-yl)-1H-indole-3-carboxaldehyde (4)、尿嘧啶(5)、对羟基苯乙胺(6)、对羟基苯乙酸(7)、对羟基苯甲酸(8)、对乙基苯甲酸(9)、2-甲基-1,4-苯二酚(10)、1,2,4-苯三酚(11)、没食子酸(12)、没食子酸-3-甲基醚(13)和4-甲氧基-3,5-羟基苯甲酸(14)。其中,1和2为新化合物,3~14为首次从马陆中分到的化合物。Fourteen compounds including two new compounds were isolated from Kronopolites svenhedini(Verhoeff).These structures were identified as kronoponit A(1),kronoponit B(2),neoechinulin A(3),2-(1,1-dimethyl-2-propen-1-yl)-1H-indole-3-carboxaldehyde(4),uracil(5),p-hydroxy phenyl ethylamine(6),p-hydroxyphenylacetic acid(7),p-hydroxybenzoic acid(8),p-ethylbenzoic acid(9),2-methyl-1,4-benzenediol(10),1,2,4-benzenetriol(11),gallic acid(12),gallic acid-3-methyl ether(13),and 4-methoxy-3,5-hydroxybenzoic acid(14)by spectroscopic methods and literature.Among them,compounds 1 and 2 are new,while compounds 3-14 are reported here for the first time from K.svenhedini.

关 键 词：宽跗陇马陆 化学成分 分离纯化 含氮化合物 芳香化合物 

分 类 号：R284[医药卫生—中药学]