靶向精氨酸代谢的肿瘤治疗进展  

Advances in Cancer Therapy by Targeting Arginine Metabolism

作　　者：盖厦梦 黄敏 GAI Xiameng;HUANG Min(School of Pharmacy,Nanchang University,Nanchang 330006,China;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Shandong Provincial Laboratory of Drug Discovery,Yantai 264117,China)

机构地区：[1]南昌大学药学院,江西南昌330006 [2]中国科学院上海药物研究所原创新药研究全国重点实验室,上海201203 [3]烟台新药创制山东省实验室,山东烟台264117

出　　处：《药学进展》2025年第4期241-254,共14页Progress in Pharmaceutical Sciences

基　　金：山东省重点研发计划(No.2024CXPT028)。

摘　　要：精氨酸是一种重要的半必需氨基酸,对于细胞维持正常的生命活动而言至关重要。精氨酸不仅作为底物参与细胞内多条代谢通路,还能作为信号分子直接参与调节细胞信号转导过程。与正常细胞相比,肿瘤细胞常常会对精氨酸代谢进行重塑,以此来满足自身快速增殖的需求。目前,靶向精氨酸代谢的抗肿瘤策略已进入临床研究阶段。近年来的研究显示,精氨酸在肿瘤微环境中的多种免疫细胞内发挥着重要作用,这为针对精氨酸代谢的肿瘤治疗策略开拓了新的研究方向。综述精氨酸作为代谢物及信号分子所具备的功能,重点讨论精氨酸代谢对肿瘤细胞以及肿瘤免疫微环境的调控作用和内在机制,同时阐述靶向精氨酸代谢的肿瘤治疗的最新进展,旨在为靶向精氨酸代谢的抗肿瘤策略提供有力的理论支持。Arginine,a semi-essential amino acid,is crucial for cells to maintain normal life activities.Arginine not only participates in multiple metabolic pathways within cells as a substrate but also directly participates in regulating the process of cell signaling transduction as a signaling molecule.Compared with normal cells,tumor cells often reshape the arginine metabolism to meet their own needs for rapid proliferation.Currently,the anti-tumor strategy targeting arginine metabolism has entered the clinical stage of research.Recent studies have shown that arginine plays an important role in various immune cells within the tumor microenvironment,which has opened up new research directions for tumor treatment strategies targeting arginine metabolism.This article reviews the functions of arginine as a metabolite and signaling molecule,with focus on the regulatory effects and internal mechanisms of arginine metabolism on tumor cells and the tumor immune microenvironment,and at the same time expounds the latest progress of tumor treatment by targeting arginine metabolism,aiming to provide robust theoretical support for anti-tumor strategy targeting arginine metabolism.

关 键 词：精氨酸 代谢 肿瘤细胞 肿瘤微环境 免疫细胞 靶向治疗 

分 类 号：R979.1[医药卫生—药品] R963[医药卫生—药学]