乳腺癌代谢与器官倾向性转移的研究进展  

Progress of Research on Metabolic and Organ Tropic Metastasis of Breast Cancer

作　　者：樊静娴 梁晓晖 靳金美 陈红专 栾鑫 FAN Jingxian;LIANG Xiaohui;JIN Jinmei;CHEN Hongzhuan;LUAN Xin(Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 200120,China)

机构地区：[1]上海中医药大学交叉科学研究院,上海200120

出　　处：《药学进展》2025年第4期281-289,共9页Progress in Pharmaceutical Sciences

基　　金：上海市中药化学生物学前沿研究基地项目(2021科技03-13)。

摘　　要：转移是乳腺癌患者死亡的重要诱因,乳腺癌常见转移部位有脑、肺、骨、肝等。乳腺癌转移过程中,各器官独特的营养环境和代谢途径可能是导致其发生倾向性转移的关键因素。综述了不同代谢途径与乳腺癌细胞转移关系的最新研究进展,深入探讨了器官营养环境和代谢途径对乳腺癌倾向性转移的影响机制,并简介通过靶向肿瘤代谢抑制乳腺癌转移的可能治疗药物。Metastasis significantly contributes to the mortality in breast cancer patients,with common metastatic sites including the brain,lungs,bones,and liver,among others.In the process of breast cancer metastasis,the unique nutritional environment and metabolic pathways of different organs may be the key factors leading to its propensity for metastasis.This review summarizes the latest research on the relationship between different metabolic pathways and breast cancer cell metastasis,and deeply explores the mechanisms by which organ nutritional environments and metabolic pathways affect the propensity for metastasis.It also briefly introduces potential therapeutic drugs that target tumor metabolism to inhibit breast cancer metastasis.

关 键 词：乳腺癌 代谢 转移 

分 类 号：R979.1[医药卫生—药品] R963[医药卫生—药学]