靶向STING药物的研究进展  

Advances in Drugs Targeting STING

作　　者：石雪松 朱娟娟 王琛 SHI Xuesong;ZHU Juanjuan;WANG Chen(School of Life Science and Technology,China Pharmaceutical University,Nanjing 21198,China;State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京211198 [2]中国药科大学多靶标天然药物全国重点实验室,江苏南京210009

出　　处：《药学进展》2025年第4期302-310,共9页Progress in Pharmaceutical Sciences

基　　金：国家重点研发计划(No.2021YFF0702003)。

摘　　要：固有免疫反应构成了宿主抵御病原体入侵的首道防线,在此过程中,环鸟苷酸-腺苷酸合酶(cyclic GMP-AMP synthase,c GAS)/干扰素基因刺激因子(stimulator of interferon gene,STING)通路发挥着核心作用。该通路不仅能够识别胞质中的双链DNA,进而触发固有免疫反应,还与抗肿瘤免疫、衰老进程、神经退行性疾病以及自身免疫病的发展存在紧密关联。综述近年来STING调控剂的研究进展,以及其在抗肿瘤疗法和自身免疫病治疗中的应用情况;探讨其在延缓衰老、治疗神经退行性疾病以及作为疫苗佐剂等方面的应用前景,旨在为靶向STING的药物研发提供参考依据。The innate immune response acts as the first line of defense for the host against pathogen invasion.Throughout the process,the cyclic GMP-AMP synthase(cGAS)/stimulator of interferon gene(STING)pathway plays a central role.This pathway not only recognizes double-stranded DNA in the cytoplasm,thus triggering the innate immune response,but also has a close association with antitumor immunity,the aging process,neurodegenerative diseases,and the development of autoimmune diseases.This review summarizes the research progress of STING regulators in recent years,as well as their application in anti-tumor therapies and treatment of autoimmune diseases;it also explores the application prospects of STING regulators in delaying aging,treating neurodegenerative diseases,and serving as vaccine adjuvants,aiming to provide some reference for the research and development of drugs targeting STING.

关 键 词：cGAS/STING通路 固有免疫 抗肿瘤免疫 自身免疫病 衰老 神经退行性疾病 药物研发 

分 类 号：R392.1[医药卫生—免疫学] R979.5[医药卫生—基础医学]