维生素A、PCT及免疫球蛋白与小儿肺炎支原体肺炎病情严重程度的相关性分析  

Correlation Analysis of Vitamin A,PCT,and Immunoglobulins with the Severity of Mycoplasma Pneumonia in Children

作　　者：张琼文 ZHANG Qiongwen(Department of Pediatrics,Shangqiu Third People’s Hospital,Shangqiu Henan 467000,China)

机构地区：[1]商丘市第三人民医院儿科,河南商丘467000

出　　处：《临床研究》2025年第5期31-34,共4页Clinical Research

摘　　要：目的探讨维生素A(VitA)、降钙素原(PCT)和免疫球蛋白对于小儿肺炎支原体肺炎病程进展的影响。方法回顾性分析2021年1月至2024年12月商丘市第三人民医院收治的肺炎支原体肺炎120例患儿的资料。按照患儿是否诊断为重症实施分组,分为轻症组和重症组。其中轻症组82例,重症组38例,并比较两组患儿血中VitA、免疫球蛋白、PCT浓度分析VitA、免疫球蛋白、PCT对肺炎支原体肺炎病情严重程度的鉴别效能。结果重症肺炎患儿的VitA水平显著下降,患儿的血清免疫球蛋白A(IgA)水平均较低,较轻症肺炎患儿的该指标水平显著低下,差异均有统计学意义(P<0.05)。而重症肺炎患儿的PCT水平明显高于轻症肺炎患儿,差异具有统计学意义(P<0.05)。两组患儿的血清免疫球蛋白M(IgM)、免疫球蛋白G(IgG)差异无统计学意义(P>0.05)。Logistic多变量分析显示,VitA、IgA和PCT对患儿的重症性均有影响,差异均有统计学意义(P<0.05)。由该分析获得的结果可以构建衡量患儿病重与否的logistic预测回归模型为:Logit(P)=4.002-7.468×VitA-0.028×IgA+11.042×PCT。根据VitA含量、体液IgA含量、PCT含量及回归模型P值测定儿童疾病的严重程度,分别依据受试者工作特征(ROC)曲线进行分析,其ROC曲线下面积分别为0.778,0.796,0.767,0.909。结论重症肺炎支原体感染患儿的VitA、IgA、PCT的变化明显,可以对患儿早期的病情严重程度进行良好的反映,能够提供必要的临床诊断信息,且联合预测效率优于单项指标,可以为临床医生判断疾病的严重程度和预后效果提供较好的参考依据。Objective To investigate the impact of Vitamin A,procalcitonin,and immunoglobulins on the progression of Mycoplasma pneumonia in children.Methods A retrospective analysis was conducted on 120 pediatric cases of Mycoplasma pneumonia treated at Shangqiu Third People’s Hospital from January 2021 to December 2024.Patients were grouped based on whether they were diagnosed with severe conditions,dividing them into mild and severe groups.There were 82 cases in the mild group and 38 cases in the severe group.Blood levels of Vitamin A,serum humoral immunoglobulins,and procalcitonin concentrations were compared between the two groups to evaluate their efficacy in differentiating the severity of Mycoplasma pneumonia.Results The serum Vitamin A levels in children with severe pneumonia were significantly lower,and the levels of serum immunoglobulin A(IgA)were also notably decreased,The levels of this indicator are significantly lower than that of children with mild pneumonia,with statistically significant differences(P<0.05).Conversely,serum were significantly higher in severe pneumonia cases than in mild cases,with a statistically significant difference(P<0.05).There were no statistically significant differences in serum immunoglobulin M(IgM)and immunoglobulin G(IgG)between the two groups(P>0.05).Logistic multivariable analysis indicated that serum Vitamin A,humoral IgA,and serum PCT significantly impacted the severity of the condition,with statistically significant differences(P<0.05).The analysis derived a logistic regression model to assess the severity of the disease in children as:Logit(P)=4.002-7.468×Vitamin A-0.028×IgA+11.042×procalcitonin.The severity of childhood diseases was determined based on serum vitamin A content,body fluid IgA content,procalcitonin content,and regression model P-value.The ROC curves of the subjects were analyzed,and the areas under the ROC curves were 0.778,0.796,0.767,and 0.909,respectively.Conclusion The changes in vitamin A,IgA,and serum procalcitonin levels in children with severe My

关 键 词：维生素 降钙素原 免疫球蛋白 肺炎支原体肺炎 感染性疾病 

分 类 号：R375.2[医药卫生—病原生物学]