硝普钠微量泵入联合西地兰改善急性左心衰伴肺水肿患者心肺功能、血氧指标的效果研究  

Study on the Effects of Cedilanid Combined with Sodium Nitroprusside Micro-Pump Infusion on Cardiorespiratory Function and Blood Oxygen Indexes in Patients with Acute Left Heart Failure and Pulmonary Edema

作　　者：刘赛磊 焦鹏[1] LIU Sailei;JIAO Peng(Department of Cardiology,Shangqiu First People's Hospital,Shangqiu Henan 476000,China)

机构地区：[1]商丘市第一人民医院心内科,河南商丘476000

出　　处：《临床研究》2025年第5期51-53,共3页Clinical Research

摘　　要：目的研究急性左心衰伴肺水肿联合应用硝普钠微量泵入、西地兰治疗的临床疗效。方法选择2022年8月至2023年8月商丘市第一人民医院收治的96例急性左心衰并肺水肿患者,使用随机数表法分组,对照组(n=48)治疗药物选用西地兰,治疗组(n=48)在对照组基础上选用硝普钠微量泵入。对两组心功能、肺功能、血氧指标和不良反应进行比较。结果治疗组左室射血分数(LVEF)、心输出量(CO)、每搏输出量(SV)均高于对照组,B型钠尿肽(BNP)低于对照组,差异均有统计学意义(P<0.05);治疗组每分钟最大通气量(MVV)、第1秒用力呼气容积(FEV_(1))和氧合指数(P/F)均高于对照组,残气量/肺总量(RV/TLC)低于对照组,差异均有统计学意义(P<0.05);治疗组的血氧饱和度(SaO_(2))高于对照组,差异具有统计学意义(P<0.05);在不良反应对比中,治疗组不良反应发生率较对照组高,差异无统计学意义(P>0.05)。结论急性左心衰并肺水肿患者使用硝普钠微量泵入配合西地兰治疗能改善心肺功能,调节血氧饱和度,但由于样本量小,且硝普钠存在低血压风险,需大样本研究进一步验证安全性。Objective To investigate the clinical efficacy of combined sodium nitroprusside micro-pump infusion and cedilanid treatment in patients with acute left heart failure accompanied by pulmonary edema.Methods A total of 96 patients with acute left heart failure and pulmonary edema treated at Shangqiu First People's Hospital from August 2022 to August 2023 were selected and randomly divided into two groups.The control group(n=48)received cedilanid,while the treatment group(n=48)was given cedilanid in conjunction with sodium nitroprusside micro-pump infusion.Cardiac function,pulmonary function,blood oxygen indexes,and adverse reactions were compared between the two groups.Results The treatment group showed higher left ventricular ejection fraction(LVEF),cardiac output(CO),and stroke volume(SV)compared to the control group,and lower levels of B-type natriuretic peptide(BNP),with statistically significant differences(P<0.05).The treatment group also had higher maximum voluntary ventilation(MVV),forced expiratory volume in one second(FEV_(1)),and oxygenation index(P/F),while residual volume/total lung capacity(RV/TLC)was lower than that of the control group,with statistically significant differences(P<0.05).Oxygen saturation(SaO_(2))in the treatment group was higher than that in the control group,showing a statistically significant difference(P<0.05).In terms of adverse reactions,the incidence rate in the treatment group was higher than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion The combined treatment of sodium nitroprusside micro-pump infusion with cedilanid in patients with acute left heart failure and pulmonary edema can improve cardiorespiratory function and regulate blood oxygen saturation.However,due to the small sample size and the risk of hypotension associated with nitroprusside,larger studies are needed to further verify its safety.

关 键 词：肺水肿 西地兰 硝普钠 急性左心衰 

分 类 号：R541.63[医药卫生—心血管疾病]