ICAM-1在病原感染中作用机制研究进展  

Progress on the mechanism of ICAM-1 in pathogen infection

作　　者：侯正阳 张雅欣 谢晶莹 冯若飞[1,2] HOU Zheng-Yang;ZHANG Ya-Xin;XIE Jing-Ying;FENG Ruo-Fei(Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine,Ministry of Education,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;College of Life Science and Engineering,Northwest Minzu University,Lanzhou 730030,China)

机构地区：[1]西北民族大学生物医学研究中心,细胞基质疫苗关键技术与产业化教育部工程研究中心,兰州730030 [2]西北民族大学生物医学研究中心,生物工程与技术国家民委重点实验室,兰州730030 [3]西北民族大学生命科学与工程学院,兰州730030

出　　处：《生命科学》2025年第3期242-249,共8页Chinese Bulletin of Life Sciences

基　　金：中央高校基本科研业务费专项资金项目(31920230160);西北民族大学引进人才科研项目(xbmuyjrc-2023015);国家自然科学基金地区基金项目(32260037)。

摘　　要：细胞黏附分子1(intercellular cell adhesion molecule-1,ICAM-1)介导细胞黏附并调控炎症应答,也是病原体入侵的重要跨膜蛋白。其作为病毒受体介导病毒的吸附、内吞运输及脱壳等过程,促进小核糖核酸病毒及流感嗜血杆菌等病原体的感染;ICAM-1还通过与LFA-1(lymphocyte function associated antigen-1,LFA-1)结合形成病毒学突触增强病毒传播效率。此外,ICAM-1可介导肿瘤细胞的黏附浸润及炎性微环境的形成。研究表明,抗体偶联药物、受体竞争性结合等靶向ICAM-1的干预策略可系统性阻断病毒吸附、抑制病毒的生命周期。本文综述了ICAM-1在促进多种病原体增殖与传播过程中的功能机制,为深入探索病毒生物学特性以及新型靶向抗病毒药物的研发提供参考依据。Cell adhesion molecule-1(ICAM-1)is a transmembrane protein,mediating cell adhesion and inflammatory response.It is a critical host protein for pathogen invasion,involving in viral adsorption,endocytosis,and uncoating through acting as viral receptor to promote the infection of multiple pathogens,such as picornaviruses and haemophilus influenzae.ICAM-1 also enhances viral transmission efficiency by binding to lymphocyte function associated antigen-1(LFA-1)to form virological synapses.Moreover,ICAM-1 can mediate the adhesion invasion of tumor cells and formation of inflammatory microenvironment during tumorigenesis.Research indicates that targeted interventions against ICAM-1,including antibody-drug conjugates and receptor-competitive binding agents,systematically block the adsorption of virus and inhibit the life cycle of viruses.Here,we review the functional mechanisms of ICAM-1 in promoting the proliferation and transmission of multiple pathogens to provide insights on further revealing virus biological characteristics and the development of novel antiviral drugs.

关 键 词：ICAM-1 病毒感染 宿主蛋白 

分 类 号：Q257[生物学—细胞生物学] R373.9[医药卫生—病原生物学]