NLRP3炎症小体在肝脏疾病中的研究进展  

Reasearch progress of NLRP3 inflammasome in liver diseases

作　　者：曹丽丽 额尔德木图[1] 莲花[1] 布仁其其格[1] 王羚鸿 赵林昀 马春丽 包玉龙[1] CAO Li-Li;E ER DE Mu-Tu;LIAN Hua;BU REN Qi-Qi-Ge;WANG Ling-Hong;ZHAO Lin-Yun;MA Chun-Li;BAO Yu-Long(Inner Mongolia Medical University,Huhhot 010000,China)

机构地区：[1]内蒙古医科大学,呼和浩特010000

出　　处：《生命科学》2025年第3期304-312,共9页Chinese Bulletin of Life Sciences

基　　金：内蒙古自治区自然科学基金项目(2021MS08029,2024MS08054,2024LHMS08024);内蒙古自治区高等学校青年科技英才支持计划(NJYT23052);内蒙古自治区高等学校创新团队发展计划(NMGIRT2418);内蒙古医科大学面上项目(YKD2021MS043);内蒙古自治区“一流学科”科研专项项目(YLXKZX-NYD-009)。

摘　　要：核苷酸结合寡聚化结构域样受体含pyrin结构域蛋白3(nucleotide-binding oligomerization domainlike receptor family pyrin domain-containing 3,NLRP3)炎症小体作为一种关键的多蛋白复合体,在肝脏疾病的发病机制中发挥重要作用。本文综述了NLRP3炎症小体的激活机制及其与急性肝损伤、肝纤维化、非酒精性脂肪性肝病、酒精性肝病和肝细胞癌等疾病的关联,强调了NLRP3抑制剂在治疗肝脏疾病中的潜力。尽管已有多种NLRP3抑制剂在实验模型中展现出良好的疗效,但其临床应用仍面临挑战。NLRP3炎症小体的异常激活与多种肝脏疾病密切相关,深入理解其作用机制对于开发新型防治手段具有重要价值。未来的研究应关注NLRP3的调控机制及个性化治疗方案的开发,以期为肝脏疾病的治疗提供新的方向。The nucleotide-binding oligomerization domain-like receptor family,pyrin domain-containing 3(NLRP3)inflammasome is a key multiprotein complex that plays an important role in the pathogenesis of liver diseases.This article describes the activation mechanism of NLRP3 inflammasome and its association with acute liver injury,hepatic fibrosis,non-alcoholic fatty liver disease,alcoholic liver disease and hepatocellular carcinoma,as well as the potential of NLRP3 inhibitors in the treatment of liver diseases.Although a variety of NLRP3 inflammasome inhibitors have shown good efficacy in experimental models,there are still challenges in clinical application.Abnormal activation of NLRP3 inflammasome is closely related to a variety of liver diseases,so in-depth understanding of its mechanism is of great value for the development of novel prevention and treatment methods.In the future,we should pay more attention to the regulatory mechanism of NLRP3 inflammasome and the development of personalized treatment,hoping to provide a new direction for the treatment of liver diseases.

关 键 词：肝脏疾病 NLRP3炎症小体 发病机制 

分 类 号：R392[医药卫生—免疫学]