奥马珠单抗治疗可升高慢性自发性荨麻疹患者外周血中维生素D的水平  

Omalizumab treatment can increase the serum levels of vitamin D in patients with chronic spontaneous urticaria

作　　者：孟珍 唐亚平 MENG Zhen;TANG Yaping(Guangzhou Dermatology Hospital,Guangzhou 510091,China)

机构地区：[1]广州市皮肤病医院,广东广州510091

出　　处：《皮肤性病诊疗学杂志》2025年第3期176-179,共4页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：市校(院)企联合资助项目(SL2024A03J01059)。

摘　　要：目的探讨奥马珠单抗治疗对慢性自发性荨麻疹(CSU)患者外周血中的维生素D[25(OH)D]的影响。方法纳入CSU患者36例,应用奥马珠单抗治疗,每4周1次,每次300 mg,连续治疗3个月。采用Spearman秩相关分析患者治疗前25(OH)D水平与UAS7的相关性。比较治疗前后的UAS7评分以及25(OH)D水平,并与对照组(36例体检健康者)进行比较。结果CSU患者治疗前的外周血25(OH)D水平与UAS7呈负相关性(r=-0.60,P=0.001)。治疗后,患者25(OH)D水平显著高于治疗前[(27.91±7.37)ng/mL vs.(18.74±6.90)ng/mL,t=5.45,P<0.001],但二者均低于对照组[(35.42±7.83)ng/mL],t值分别为4.19、9.59,P值均<0.001;UAS7值较治疗前显著降低[(2.00±3.00)vs.(22.03±5.05),U=20.48,P<0.001]。结论奥马珠单抗治疗可提高慢性自发性荨麻疹患者血清中25(OH)D水平。25(OH)D可能在慢性自发性荨麻疹的发病机制中具有一定保护作用。Objective To investigate the effect of omalizumab treatment on circulating levels of 25(OH)D in patients with chronic spontaneous urticaria(CSU).Methods Thirty-six patients with CSU were treated with 300 mg of omalizumab once every 4 weeks for 3 months.Spearman rank correlation analysis was performed to determine the correlation between UAS7 and 25(OH)D levels before the treatment.UAS7 scores and 25(OH)D levels in patients were compared before and after the treatment,and with those in the controls(36 healthy subjects).Results UAS7 was negatively correlated with 25(OH)D levels in peripheral blood of CSU patients before the treatment(r=-0.60,P=0.001).The 25(OH)D levels were significantly higher after the treatment than before the treatment[(27.91±7.37)ng/mL vs.(18.74±6.90)ng/mL,t=5.45,P<0.001].However,both of them were lower than the normal controls[(35.42±7.83)ng/mL],t=4.19,9.59,respectively,both P<0.001.After the treatment,UAS7 was significantly lower than that before the treatment[(2.00±3.00)vs.(22.03±5.05),U=20.48,P<0.001].Conclusions Omalizumab treatment can increase the serum 25(OH)D levels in patients with chronic spontaneous urticaria.25(OH)D may play a protective role in the pathogenesis of chronic spontaneous urticaria.

关 键 词：慢性自发性荨麻疹 奥马珠单抗 25(OH)D 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]