梅毒螺旋体黏附蛋白与宿主细胞间的作用研究进展  

Research progress on the interactions between Treponema pallidum adhesion proteins and host cells

作　　者：黄佳林 郑举敦 HUANG Jialin;ZHENG Judun(Dermatology Hospital,Southern Medical University,Guangzhou 510091,China)

机构地区：[1]南方医科大学皮肤病医院,广东广州510091

出　　处：《皮肤性病诊疗学杂志》2025年第3期215-221,共7页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：国家自然科学基金(82102444);广东省普通高校重点领域专项项目(2023ZDZX202);广州市基础与应用基础研究专题青年博士“启航”项目(SL2024A04J01463)。

摘　　要：梅毒螺旋体(Tp)由围绕其周质空间的外膜、肽聚糖、细胞质膜与原生质构成,其脂多糖和跨膜蛋白丰度均较低,使其能够隐藏自身从而具有强大的组织侵袭与免疫逃逸能力。粘附介导的定植在Tp感染的发病机制中起着重要作用。体外研究表明,Tp可以粘附在人类和其他哺乳动物的细胞上,并更倾向与某些细胞表面的特定分子相互作用,从而影响Tp的入侵、致病性以及免疫逃逸。本文综述Tp黏附蛋白如何与不同宿主细胞进行相互作用从而引发进一步的侵袭与感染,并对这些蛋白在梅毒发病机制中的作用进行概括,以期为梅毒发生发展、疫苗及新型治疗药物开发研究提供重要参考。Treponema pallidum(Tp)has an outer membrane that encircles the periplasmic space,the peptidoglycan,cytoplasmic membrane,and protoplasmic components.The low abundance of lipopolysaccharides and transmembrane proteins enable it to conceal itself and to exert robust capabilities for tissue invasion and immune escape.Adhesion-mediated colonization plays a significant role in the pathogenesis of syphilis caused by Tp.In vitro studies have shown that Tp can adhere to cells of humans and other mammals,with a preference for interacting with specific molecules on certain cell surfaces,thereby influencing the invasion,pathogenicity and immune escape of Tp.This review summarizes how adhesion proteins of Tp interact with various host cells to trigger invasion and infection,and overviews their role in syphilis pathogenesis,aiming to offer significant insights for research into etiology,vaccine development,and the discovery of novel therapeutic agents for syphilis.

关 键 词：梅毒螺旋体 黏附蛋白 宿主细胞 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]