大疱性类天疱疮与2型糖尿病相关性的研究进展  

Research progress on the association of bullous pemphigoid with type 2 diabetes mellitus

作　　者：张若菡 王震英 ZHANG Ruohan;WANG Zhenying(Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China;Shandong First Medical University,Jinan 250117,China)

机构地区：[1]山东第一医科大学附属省立医院,山东济南250021 [2]山东第一医科大学,山东济南250117

出　　处：《皮肤性病诊疗学杂志》2025年第3期222-227,共6页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：大疱性类天疱疮(BP)是一种常见的好发于老年群体的自身免疫性大疱性疾病。BP患者中糖尿病(DM)的发生率高于一般人群,并且合并DM被认为是BP的预后不良因素。大量流行病学证据已表明BP与DM之间存在相关性,两者之间的关联可能受年龄、免疫状态、药物使用、遗传因素等影响,但其中的因果关系尚未明确。同时早期监测BP患者血糖水平,选取合理的治疗方案对控制病情及改善预后有较大意义。本文从BP与2型糖尿病(T2DM)的流行病学、发病机制、临床特征与治疗几方面进行综述,为进一步研究两者的联系和潜在机制提供参考。Bullous pemphigoid(BP)is a common autoimmune bullous disease that predominantly affects the elderly.The incidence of diabetes mellitus(DM)is higher in BP patients than in the general population,and the coexistence of diabetes is considered an adverse prognostic factor in BP patients.A substantial amount of epidemiological evidence has demonstrated an association between the two conditions.The link between them may be influenced by factors,such as age,immune status,use of medication,and genetic predisposition.However,their causal relationship remains unclear.Early monitoring of blood glucose levels in BP patients and the selection of appropriate treatment strategies are crucial for controlling the disease and improving prognosis.This review describes the relationship between the two conditions from the aspects of epidemiology,pathogenesis,clinical characteristics,and treatment,in order to provide references for further research into their connection and potential mechanisms.

关 键 词：大疱性类天疱疮 2型糖尿病 自身免疫性疾病 二肽基肽酶-4抑制剂 

分 类 号：R587.2[医药卫生—内分泌]