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作 者:徐蔓玲 XU Man-Ling(Shengda Mingrui(Beijing)International Pharmaceutical Technology Co.,LTD.,Beijing 102300,China)
机构地区:[1]晟大铭瑞(北京)国际医药科技有限公司,北京102300
出 处:《中国药物经济学》2025年第3期29-32,38,共5页China Journal of Pharmaceutical Economics
摘 要:目的比较通络开痹片加载基础治疗与尪痹胶囊加载基础治疗治疗类风湿关节炎(RA)的经济性。方法基于全社会角度,获取通络开痹片与尪痹胶囊的真实世界研究数据,对比分析通络开痹片与尪痹胶囊治疗RA的临床疗效。从药智数据网获得两种药品价格,利用Treeage Pro 2018.2.1软件建立决策树模型,计算增量成本-效果比(ICER),并进行单因素敏感性分析。结果以第12周达到或维持临床缓解或低疾病活动度(DAS28评分≤3.2分)的受试者比例为结局指标时,通络开痹片组与尪痹胶囊组相比的增量成本为-436.38元,增量效果为14.00%,两组的ICER值为-31.17元。相较于对照组(尪痹胶囊组),通络开痹片组的成本更低,而疗效更佳,因此通络开痹片加载基础治疗为绝对优势方案。单因素敏感性分析,两药以DAS28评分≤3.2分达标比例为结局指标时,通络开痹片组及尪痹胶囊组的成本对结果影响较大,两组患者的达标比例对结果影响不大。结论通络开痹片加载基础治疗与尪痹胶囊加载基础治疗相比,在治疗RA的DAS28评分≤3.2分达标比例方面有经济性优势,且为绝对优势方案。Objective To compare the economic efficacy of Tongluo Kaibi tablets combined with basic therapy versus Wangbi capsules combined with basic therapy in the treatment of Rheumatoid Arthritis(RA).Methods Based on a whole-of-society perspective,the real world research data of Tongluo Kaibi tablets and Wangbi capsules were obtained,and the clinical effects of Tongluo Kaibi tablets and Wangbi capsules were compared.The prices of two drugs were obtained from the data of Drugwise,and the decision tree model was established by using Treeage Pro2018.2.1 software to calculate the incremental cost-effectiveness ratio(ICER),and the economy of the two drugs was compared by single factor sensitivity analysis.Results When the proportion of subjects who achieved or maintained clinical remission or low disease activity(DAS28 score≤3.2 points)at the 12th week was taken as the outcome index,the incremental cost and effect of Tongluo Kaibi tablets group were-436.38 yuan and 14.00%respectively,and the ICER value of the two groups was-31.17 yuan.The cost of Tongluo Kaibi Tablets group is lower and the effect is better than that of the control group(Wangbi capsules group),so the basic treatment of Tongluo Kaibi tablets loading is an absolute advantage.Univariate sensitivity analysis showed that when the DAS28 score≤3.2 was used as the outcome index,the cost of Tongluo Kaibi tablets group and Wangbi capsules group had a significant impact on the results,and the target proportion of patients in the two groups had little impact on the results.Conclusion It is concluded that the basic treatment of Tongluo Kaibi tablets loading has an economic advantage in terms of the target ratio(DAS28 score≤3.2 points)in the treatment of RA,and it is an absolute advantage program.
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