Study on the influence of the sY1192 gene locus in the AZFb/c region on sperm quality and pregnancy outcome  

作　　者：Gang-Xin Chen Yan Sun Rui Yang Zhi-Qing Huang Hai-Yan Li Bei-Hong Zheng 

机构地区：[1]Center of Reproductive Medicine,Fujian Maternity and Child Health Hospital,College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics,Fujian Medical University,Fuzhou 350001,China [2]Fujian Maternal-Fetal Clinical Medicine Research Center,Fuzhou 350001,China [3]Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect,Fuzhou 350001,China

出　　处：《Asian Journal of Andrology》2025年第2期231-238,共8页亚洲男性学杂志(英文版)

基　　金：supported by the funding from the Joint Funds for the Innovation of Science and Technology,Fujian Province(Grant No.2023Y9385);Major Scientific Research Program for Young and Middleaged Health Professionals of Fujian Province,China(Grant No.2022ZQNZD010).

摘　　要：Y chromosome microdeletions are an important cause of male infertility.At present,research on the Y chromosome is mainly focused on analyzing the loss of large segments of the azoospermia factor a/b/c(AZFa/b/c)gene,and few studies have reported the impact of unit point deletion in the AZF band on fertility.This study analyzed the effect of sperm quality after sY1192 loss in 116 patients.The sY1192-independent deletion accounted for 41.4%(48/116).Eight patterns were found in the deletions associated with sY1192.The rate of sperm detection was similar in the semen of patients with the independent sY1192 deletion and the combined sY1192 deletions(52.1%vs 50.0%).The patients with only sY1192 gene loss had a higher probability of sperm detection than the patients whose sY1192 gene locus existed,but other gene loci were lost(52.1%vs 32.0%).The hormone levels were similar in patients with sY1192 deletion alone and in those with sY1192 deletion and other types of microdeletions in the presence of the sY1192 locus.After multiple intracytoplasmic sperm injection(ICSI)attempts,the pregnancy rate of spouses of men with sY1192-independent deletions was similar to that of other types of microdeletions,but the fertilization and cleavage rates were higher.We observed that eight deletion patterns were observed for sY1192 microdeletions of AZFb/c,dominated by the independent deletion of sY1192.After ICSI,the fertilization rate and cleavage rate of the sY1192-independent microdeletion were higher than those of other Y chromosome microdeletion types,but there was no significant difference in pregnancy outcomes.

关 键 词：assisted reproductive technology AZFb/c pregnancy outcome sY1192 Y chromosome microdeletion 

分 类 号：R69[医药卫生—泌尿科学]