烟酰胺注射液联合琥珀酸美托洛尔缓释片治疗急性心肌梗死患者的效果  

Effects of Nicotinamide injection combined with Metoprolol succinate sustained-release tablets in treatment of patients with acute myocardial infarction

作　　者：孙燕燕 尚志豪 SUN Yanyan;SHANG Zhihao(First Department of Internal Medicine of Xiangfu District Hospital of Traditional Chinese Medicine,Kaifeng 475100 Henan,China)

机构地区：[1]开封市祥符区中医院内一科,河南开封475100

出　　处：《中国民康医学》2025年第8期26-29,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察烟酰胺注射液联合琥珀酸美托洛尔缓释片治疗急性心肌梗死患者的效果。方法:回顾性分析2021年1月至2023年11月该院收治的80例急性心肌梗死患者的临床资料,依据治疗方案不同将其分为对照组与观察组各40例。对照组采用琥珀酸美托洛尔缓释片治疗,观察组在对照组基础上联合烟酰胺注射液治疗,比较两组临床疗效,治疗前后心功能指标[心脏指数(CI)、心排血量(CO)、每搏输出量(SV)、左心室射血分数(LVEF)]、炎性指标[粒细胞巨噬细胞集落刺激因子2受体α(CSF2RA)、巨噬细胞迁移抑制因子(MIF)]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,两组CO、CI、SV、LVEF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组CSF2RA、MIF水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组MDA水平均低于治疗前,且观察组低于对照组,两组SOD水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:烟酰胺注射液联合琥珀酸美托洛尔缓释片治疗急性心肌梗死患者可提高治疗总有效率,改善心功能指标与氧化应激指标水平,以及降低炎性指标水平的效果优于单纯琥珀酸美托洛尔缓释片治疗。Objective:To observe effects of Nicotinamide injection combined with Metoprolol succinate sustained-release tablets in treatment of patients with acute myocardial infarction.Methods:The clinical data of 80 patients with acute myocardial infarction admitted to this hospital from January 2021 to November 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group and observation group,40 cases in each group.The control group was treated with Metoprolol succinate sustained-release tablets,while the observation group was treated with Nicotinamide injection on the basis of that of the control group.The clinical efficacies,the levels of cardiac function indexes[cardiac index(CI),cardiac output(CO),stroke volume(SV),left ventricular ejection fraction(LVEF)],inflammatory indexes[granulocyte-macrophage colony-stimulating factor receptorα(CSF2RA),macrophage migration inhibitory factor(MIF)]and oxidative stress indexes[malondialdehyde(MDA),superoxide dismutase(SOD)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.00%,which was higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CO,CI,SV and LVEF in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of CSF2RA and MIF in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The MDA levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the SOD levels of the two groups were higher than those before the treatment,and that in the observation group was higher

关 键 词：烟酰胺注射液 琥珀酸美托洛尔缓释片 急性心肌梗死 心功能 炎性指标 氧化应激指标 不良反应 

分 类 号：R543.3[医药卫生—心血管疾病]