头孢曲松钠联合阿奇霉素治疗肺炎链球菌肺炎患儿的效果  

Effects of Ceftriaxone sodium combined with Azithromycin in treatment of children with Streptococcus pneumoniae pneumonia

作　　者：陈思 CHEN Si(Department of Traditional Chinese Medicine Pediatrics of Minhou County People’s Hospital,Fujian 350121 Fuzhou,China)

机构地区：[1]闽侯县人民医院中医儿科,福建福州350121

出　　处：《中国民康医学》2025年第8期44-47,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察头孢曲松钠联合阿奇霉素治疗肺炎链球菌肺炎患儿的效果。方法:选取2023年1—12月该院收治的90例肺炎链球菌肺炎患儿进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各45例。对照组给予阿奇霉素治疗,观察组在对照组基础上联合头孢曲松钠治疗。比较两组临床疗效,临床症状(发热、咳嗽、肺部湿啰音)消失时间和住院时间,治疗前后肺功能指标[第1秒用力呼气容积(FEV_(1))、呼气流量峰值(PEF)、用力肺活量(FVC)]、炎性因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.56%(43/45),高于对照组的82.22%(37/45),差异有统计学意义(P<0.05);观察组发热、咳嗽、肺部湿啰音消失时间和住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组FEV_(1)、PEF、FVC水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组IL-6、TNF-α、CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:头孢曲松钠联合阿奇霉素治疗肺炎链球菌肺炎患儿,可提高临床疗效,缩短临床症状消失时间和住院时间,改善肺功能,减轻机体炎症反应,效果优于单纯阿奇霉素治疗。Objective:To observe effects of Ceftriaxone sodium combined with Azithromycin in treatment of children with Streptococcus pneumoniae pneumonia.Methods:A prospective study was conducted on 90 children with pneumococcal pneumonia admitted to this hospital from January to December 2023.According to the random number table method,they were divided into control group and observation group,45 cases in each group.The control group was treated with Azithromycin,while the observation group was treated with Ceftriaxone sodium on the basis of that of the control group.The clinical efficacies,the disappearance time of clinical symptoms(fever,cough,pulmonary rales)and the hospitalization time,the lung function indexes[forced expiratory volume in one second(FEV_(1)),peak expiratory flow(PEF),forced vital capacity(FVC)]levels,the inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.56%(43/45),which was higher than 82.22%(37/45)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,cough,lung moist rale and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV_(1),PEF and FVC in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of IL-6,TNF-αand CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ceftriaxon

关 键 词：头孢曲松钠 阿奇霉素 肺炎链球菌 肺功能 不良反应 

分 类 号：R725.6[医药卫生—儿科]