双歧杆菌四联活菌联合常规四联疗法治疗幽门螺杆菌阳性胃溃疡患者的效果  

Effects of combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live combined with conventional quadruple therapy in treatment of Helicobacter pylori positive gastric ulcer

作　　者：高原 白宁 GAO Yuan;BAI Ning(Department of Gastroenterology of Xinyang Maternal and Child Health Hospital,Xinyang 464000 Henan,China;Department of Gastroenterology of Huaihe Hospital of Henan University,Kaifeng 475000 Henan,China)

机构地区：[1]信阳市妇幼保健院消化内科,河南信阳464000 [2]河南大学淮河医院消化内科,河南开封475000

出　　处：《中国民康医学》2025年第8期55-57,61,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察双歧杆菌四联活菌联合常规四联疗法治疗幽门螺杆菌(Hp)阳性胃溃疡患者的效果。方法:选取2021年1月至2023年3月信阳市妇幼保健院收治的94例Hp阳性胃溃疡患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各47例。对照组给予常规四联疗法治疗,观察组在对照组基础上联合双歧杆菌四联活菌治疗。比较两组Hp清除率,溃疡愈合率,治疗前后肠道菌群指标(嗜酸乳杆菌、双歧杆菌、酵母菌、粪肠球菌)、胃肠激素指标[胃泌素-17(GAS-17)、胃动素(MTL)、胃蛋白酶Ⅰ(PGⅠ)]、炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-3(MMP-3)]水平,不良反应发生率,以及1年Hp复发率。结果:治疗后,观察组Hp清除率、溃疡愈合率均高于对照组,差异有统计学意义(P<0.05);治疗后,观察组嗜酸乳杆菌、双歧杆菌、粪肠球菌水平均高于治疗前且高于对照组,对照组嗜酸乳杆菌、双歧杆菌、粪肠球菌水平均低于治疗前,两组酵母菌水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组MTL水平均高于治疗前,且观察组高于对照组,两组GAS-17、PGⅠ水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组IL-6、TNF-α及MMP-3水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率和1年Hp复发率均低于对照组,差异有统计学意义(P<0.05)。结论:双歧杆菌四联活菌联合常规四联疗法治疗Hp阳性胃溃疡患者可提高Hp清除率和溃疡愈合率,改善肠道菌群指标和胃肠激素指标水平,以及降低不良反应发生率和1年Hp复发率的效果优于单纯常规四联疗法治疗。Objective:To observe effects of combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live combined with conventional quadruple therapy in treatment of patients with Helicobacter pylori(Hp)-positive gastric ulcer.Methods:A prospective study was conducted on 94 patients with Hp-positive gastric ulcer admitted to Xinyang Maternal and Child Health Hospital from January 2021 to March 2023.According to the random number table method,they were divided into control group and observation group,47 cases in each group.The control group was treated with conventional quadruple therapy,while the observation group was treated with combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live on the basis of that of the control group.The Hp clearance rate,the ulcer healing rate,the levels of intestinal flora indexes(Lactobacillus acidophilus,Bifidobacterium,Saccharomycetales,Enterococcus faecalis),gastrointestinal hormone indexes[gastrin-17(GAS-17),motilin(MTL),pepsin I(PGI)]and inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),matrix metalloproteinase-3(MMP-3)],the incidence of adverse reactions,and the 1-year Hp recurrence rate were compared between the two groups.Results:After the treatment,the Hp clearance rate and the ulcer healing rate in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of Lactobacillus acidophilus,Bifidobacterium and Enterococcus faecalis in the observation group were higher than those before the treatment,and were higher than those in the control grou,and the levels of Lactobacillus acidophilus,Bifidobacterium and Enterococcus faecalis in the control group were lower than those before the treatment;the Saccharomycetales levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).The MTL

关 键 词：双歧杆菌四联活菌 常规四联疗法 胃溃疡 肠道菌群 胃肠激素 不良反应 

分 类 号：R713.3[医药卫生—妇产科学]