阿达木单抗联合卡泊三醇软膏治疗重度银屑病患者的效果  

Effects of Adalimumab combined with Calcipotriol ointment in treatment of patients with severe psoriasis

作　　者：王传龙 WANG Chuanlong(Department of Dermatology of Dancheng County Hospital of Traditional Chinese Medicine,Zhoukou 477150 Henan,China)

机构地区：[1]郸城县中医院皮肤科,河南周口477150

出　　处：《中国民康医学》2025年第8期65-67,71,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察阿达木单抗联合卡泊三醇软膏治疗重度银屑病患者的效果。方法:选取2021年9月至2023年9月该院收治的68例重度银屑病患者进行前瞻性研究,按照随机数字表法将其分为对照组(n=34)和观察组(n=34)。对照组予以卡泊三醇软膏治疗,观察组在对照组基础上联合阿达木单抗治疗,比较两组临床疗效,临床症状(鳞屑、红斑、脱屑、瘙痒)缓解时间,治疗前后炎性指标[γ干扰素(IFN-γ)、白细胞介素-17(IL-17)、白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)]水平、生命质量[世界卫生组织生存质量测定简表(WHOQOL-BREF)]评分,以及不良反应发生率。结果:观察组治疗总有效率为94.12%(32/34),高于对照组的73.53%(25/34),差异有统计学意义(P<0.05);观察组鳞屑、红斑、脱屑、瘙痒等临床症状缓解时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组IFN-γ、IL-17、IL-2、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组环境领域、心理领域、生理领域、社会关系领域等WHOQOL-BREF评分均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿达木单抗联合卡泊三醇软膏治疗重度银屑病患者可提高治疗总有效率和生命质量评分,缩短临床症状缓解时间,降低炎性指标水平,效果优于单纯卡泊三醇软膏治疗。Objective:To observe effects of Adalimumab combined with Calcipotriol ointment in treatment of patients with severe psoriasis.Methods:A prospective study was conducted on 68 patients with severe psoriasis admitted to the hospital from September 2021 to September 2023.According to the random number table method,they were divided into control group(n=34)and observation group(n=34).The control group was treated with Calcipotriol ointment,while the observation group was treated with Adalimumab on the basis of that of the control group.The clinical efficacies,the remission time of clinical symptoms(scales,erythema,desquamation,itching),the levels of inflammatory factors[interferon-γ(IFN-γ),interleukin-17(IL-17),interleukin-2(IL-2),tumor necrosis factor-α(TNF-α)],the scores of quality of life[World Health Organization quality of life-Brief(WHOQOL-BREF)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.12%(32/34),which was higher than 73.53%(25/34)of the control group,and the difference was statistically significant(P<0.05).The remission time of clinical symptoms such as scales,erythema,desquamation and itching in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IFN-γ,IL-17,IL-2 and TNF-αin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of WHOQOL-BREF in the environmental field,psychological field,physiological field and social relationship field in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Adalimumab combined with Calcipotriol ointment in the treatment of the patients with sever

关 键 词：重度银屑病 卡泊三醇软膏 阿达木单抗 生命质量 炎性指标 不良反应 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]