纳布啡联合丙泊酚在宫腔镜手术患者麻醉中的应用效果  

Application effects of Nalbuphine combined with Propofol in anesthesia of patients undergoing hysteroscopic surgeries

作　　者：傅文敏 袁得生 严忠 FU Wenmin;YUAN Desheng;YAN Zhong(Department of Anesthesiology of Fenyi County People’s Hospital,Xinyu 336600 Jiangxi,China)

机构地区：[1]分宜县人民医院麻醉科,江西新余336600

出　　处：《中国民康医学》2025年第8期78-80,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察纳布啡联合丙泊酚在宫腔镜手术患者麻醉中的应用效果。方法:选取2021—2023年该院收治的行宫腔镜手术治疗的60例子宫内膜息肉患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各30例。对照组采用舒芬太尼联合丙泊酚麻醉,观察组采用纳布啡联合丙泊酚麻醉,比较两组不同时间[麻醉前(T_(0))、麻醉后10 min(T_(1))、术毕时(T_(2))]血流动力学指标[心率、平均动脉压(MAP)]水平、手术前后应激反应指标[去甲肾上腺素(NE)、皮质醇(Cor)]水平、苏醒指标(睁眼时间、苏醒期躁动发生率)水平和术后24 h不良反应发生率。结果:T_(0)时,两组心率、MAP水平比较,差异均无统计学意义(P>0.05);T_(1)、T_(2)时,观察组心率、MAP水平均高于对照组,差异有统计学意义(P<0.05);T_(2)时,两组NE、Cor水平均高于术前,但观察组低于对照组,差异有统计学意义(P<0.05);观察组睁眼时间短于对照组,苏醒期躁动发生率低于对照组,差异均有统计学意义(P<0.05);观察组不良反应发生率为6.67%(2/30),低于对照组的26.67%(8/30),差异有统计学意义(P<0.05)。结论:纳布啡联合丙泊酚应用于宫腔镜手术患者麻醉中可提高血流动力学指标水平,降低应激反应指标水平和不良反应发生率,改善苏醒指标水平,效果优于舒芬太尼联合丙泊酚麻醉。Objective:To observe application effects of Nalbuphine combined with Propofol in anesthesia of patients undergoing hysteroscopic surgeries.Methods:A prospective study was conducted on 60 patients with endometrial polyps who underwent hysteroscopic surgeries in this hospital from 2021 to 2023.According to the random number table method,they were divided into control group and observation group,30 cases in each group.The control group was anesthetized with Sufentanil combined with Propofol,while the observation group was anesthetized with Nalbuphine combined with Propofol.The levels of hemodynamic indexes[heart rate,mean arterial pressure(MAP)]at different time[before anesthesia(T_(0)),10 min after anesthesia(T_(1)),at the end of the surgery(T_(2))]and stress response indexes[norepinephrine(NE),cortisol(Cor)]before and after the surgery,the recovery indexes(eye opening time,incidence of agitation during recovery period),and the incidence of adverse reactions 24 h after the surgery were compared between the two groups.Results:At T_(0),there were no significant differences in the heart rate and MAP levels between the two groups(P>0.05).At T_(1) and T_(2),the heart rate and MAP levels of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).At T_(2),the levels of NE and Cor in the two groups were higher than those before the surgery,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The postoperative eye opening time of the observation group was shorter than that of the control group,the incidence of agitation in the recovery period was lower than that of the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 6.67%(2/30),which was lower than 26.67%(8/30)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Nalbuphine combined with Propo

关 键 词：子宫内膜息肉 宫腔镜手术 纳布啡 丙泊酚 舒芬太尼 血流动力学 应激反应 

分 类 号：R614[医药卫生—麻醉学]