小剂量阿司匹林联合硝苯地平治疗妊娠期高血压疾病患者的效果  

Effects of low-dose Aspirin combined with Nifedipine in treatment of patients with hypertensive disorder complicating pregnancy

作　　者：王素巧 陈远琼 WANG Suqiao;CHEN Yuanqiong(Department of Obstetrics and Gynecology of Pingdingshan Family Planning Hospital,Pingdingshan 467000 Henan,China;Department of Obstetrics of Baofeng County People’s Hospital,Pingdingshan 467400 Henan,China)

机构地区：[1]平顶山计生医院妇产科,河南平顶山467000 [2]宝丰县人民医院产科,河南平顶山467400

出　　处：《中国民康医学》2025年第8期81-84,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察小剂量阿司匹林联合硝苯地平治疗妊娠期高血压疾病患者的效果。方法:选取2019年1月至2024年1月平顶山计生医院收治的100例妊娠期高血压疾病患者进行前瞻性研究,根据随机数字表法将其分为对照组和研究组各50例。对照组采用硝苯地平治疗,研究组在对照组基础上联合小剂量阿司匹林治疗,比较两组临床疗效,治疗前后血压、血液流变学指标水平,以及不良母婴结局和不良反应发生率。结果:研究组治疗总有效率为88.00%(44/50),高于对照组的72.00%(36/50),差异有统计学意义(P<0.05);治疗后,两组收缩压、舒张压水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组全血高切黏度、全血低切黏度、血浆黏度均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组不良母婴结局发生率为12.00%(6/50),低于对照组的30.00%(15/50),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小剂量阿司匹林联合硝苯地平治疗妊娠期高血压疾病患者可提高治疗总有效率,降低血压、血液流变学指标水平和不良母婴结局发生率,效果优于单纯硝苯地平治疗。Objective:To observe effects of low-dose Aspirin combined with Nifedipine in treatment of patients with hypertensive disorder complicating pregnancy.Methods:A prospective study was conducted on 100 patients with hypertensive disorder complicating pregnancy admitted to Pingdingshan Family Planning Hospital from January 2019 to January 2024.According to the random number table method,they were divided into control group and study group,50 cases in each group.The control group was treated with Nifedipine,while the study group was treated with lowdose Aspirin on the basis of that of the control group.The clinical efficacies,the blood pressure and hemorheology indexes levels before and after the treatment,and the incidence of adverse maternal and infant outcomes and adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 88.00%(44/50),which was higher than 72.00%(36/50)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of systolic blood pressure and diastolic blood pressure in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse maternal and infant outcomes in the study group was 12.00%(6/50),which was lower than 30.00%(15/50)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Low-dose Aspirin combined with Nifedipine in the treatment of the patients with hypertensive disorder complicating

关 键 词：妊娠期高血压疾病 阿司匹林 硝苯地平 血压 血液流变学 不良母婴结局 不良反应 

分 类 号：R714.2[医药卫生—妇产科学]