间苯三酚联合地屈孕酮治疗先兆流产患者的效果  

Effects of Phloroglucinol combined with Dydrogesterone in treatment of threatened abortion

作　　者：邵若男 SHAO Ruonan(Department of Obstetrics and Gynecology of Xiayi County Maternal and Child Health Hospital,Shangqiu 476400 Henan,China)

机构地区：[1]夏邑县妇幼保健院妇产科,河南商丘476400

出　　处：《中国民康医学》2025年第8期85-88,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察间苯三酚联合地屈孕酮治疗先兆流产患者的效果。方法:回顾性分析2021年1月至2023年1月该院收治的94例先兆流产患者的临床资料,按照治疗方案不同将其分为对照组和研究组各47例。对照组给予地屈孕酮治疗,研究组在对照组基础上联合间苯三酚治疗。比较两组临床疗效,治疗前后子宫动脉血流动力学指标[收缩期/舒张期比值(S/D)、搏动指数(PI)、阻力指数(RI)]、性激素指标[雌二醇、孕酮、β-人绒毛膜促性腺激素(β-hCG)]、血清炎性介质指标[白细胞介素-6(IL-6)、核苷酸结合结构域富含亮氨酸重复序列和含热蛋白结构域受体3(NLRP3)、高迁移率族蛋白B1(HMGB1)、肿瘤坏死因子-α(TNF-α)]水平,妊娠结局(足月妊娠率、流产率、早产率),以及治疗期间不良反应发生率。结果:研究组治疗总有效率为97.87%(46/47),高于对照组的82.98%(39/47),差异有统计学意义(P<0.05);治疗后,两组RI、PI、S/D水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组雌二醇、孕酮、β-hCG水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α、HMGB1、NLRP3水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组足月妊娠率为87.23%(41/47),高于对照组的70.21%(33/47),流产率为4.26%(2/47),低于对照组的17.02%(8/17),差异均有统计学意义(P<0.05);两组早产率比较,差异无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:间苯三酚联合地屈孕酮治疗先兆流产患者可提高治疗总有效率、性激素指标水平和足月妊娠率,降低子宫动脉血流动力学指标水平、血清炎性介质指标水平和流产率,效果优于单纯地屈孕酮治疗。Objective:To observe effects of Phloroglucinol combined with Dydrogesterone in treatment of patients with threatened abortion.Methods:The clinical data of 94 patients with threatened abortion admitted to this hospital from January 2021 to January 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group and study group,47 cases in each group.The control group was treated with Dydrogesterone,while the study group was treated with Phloroglucinol on the basis of that of the control group.The clinical efficacy,the levels of uterine artery hemodynamics[systolic/diastolic ratio(S/D),pulsatility index(PI),resistance index(RI)],sex hormone indexes[estradiol,progesterone,β-human chorionic gonadotropin(β-hCG)],serum inflammatory mediators[interleukin-6(IL-6),nucleotide binding domain rich in leucine repeats and heat-containing protein domain receptor 3(NLRP3),high mobility group protein B1(HMGB1)and tumor necrosis factor-α(TNF-α)]before and after the treatment,the pregnancy outcomes(full-term pregnancy rate,abortion rate,preterm birth rate),and the incidence of adverse reactions during the treatment were compared between the two groups.Results:The total effective rate of treatment in the study group was 97.87%(46/47),which was higher than 82.98%(39/47)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of RI,PI and S/D in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of estradiol,progesterone andβ-hCG in the two groups were higher than those before the treatment,those in the study group were higher than the control group,those in the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-α,HMGB1 and NLRP3 in the two groups were lower than those before the treatment,those in the study group were lower t

关 键 词：间苯三酚 地屈孕酮 先兆流产 性激素 血流动力学 高迁移率族蛋白B1 妊娠结局 

分 类 号：R714.21[医药卫生—妇产科学]