低分子肝素钠联合间苯三酚治疗孕早期先兆流产患者的效果  

Effects of low molecular weight Heparin sodium combined with Phloroglucinol in treatment of patients with threatened abortion in early pregnancy

作　　者：张果鲜 ZHANG Guoxian(Second Ward of Department of Obstetrics of Ruzhou People’s Hospital,Ruzhou 467599 Henan,China)

机构地区：[1]汝州市人民医院产科二病区,河南汝州467599

出　　处：《中国民康医学》2025年第8期89-91,101,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察低分子肝素钠联合间苯三酚治疗孕早期先兆流产患者的效果。方法:选取2020年7月至2022年7月该院收治的84例孕早期先兆流产患者进行前瞻性研究,按随机数字表法将其分为对照组与研究组各42例。对照组采用间苯三酚治疗,研究组在对照组基础上联合低分子肝素钠治疗。比较两组临床症状消失时间,治疗前后性激素[人绒毛膜促性腺激素(β-hCG)、孕酮、雌二醇(E_(2))]、凝血功能指标[D-二聚体(D-D)、纤维蛋白原(FIB)]水平,妊娠结局,以及不良反应发生率。结果:研究组腰酸、腹痛、阴道出血等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗7 d后,两组β-hCG、孕酮、E_(2)水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组D-D水平均低于治疗前,且研究组低于对照组,两组FIB水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组早产、流产发生率比较,差异均无统计学意义(P>0.05);研究组足月妊娠率为92.86%,高于对照组的76.19%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:低分子肝素钠联合间苯三酚治疗孕早期先兆流产患者可提高性激素水平和足月妊娠率,缩短临床症状消失时间,以及改善凝血功能指标水平的效果优于单纯间苯三酚治疗。Objective:To observe effects of low molecular weight Heparin sodium combined with Phloroglucinol in treatment of patients with threatened abortion in early pregnancy.Methods:A prospective study was conducted on 84 patients with threatened abortion in early pregnancy admitted to this hospital from July 2020 to July 2022.According to the random number table method,they were divided into control group and study group,42 cases in each group.The control group was treated with Phloroglucinol,while the study group was treated with low molecular weight Heparin sodium on the basis of that of the control group.The disappearance time of clinical symptoms,the levels of sex hormones[human chorionic gonadotropin(β-hCG),progesterone,estradiol(E_(2))]and coagulation function indexes[D-dimer(D-D),fibrinogen(FIB)]before and after the treatment,the pregnancy outcome,and the incidence of adverse reactions were compared between the two groups.Results:The disappearance time of clinical symptoms such as waist soreness,abdominal pain and vaginal bleeding in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After 7 days of treatment,the levels ofβ-hCG,progesterone and E_(2) in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The D-D levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the FIB levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of premature delivery and abortion between the two groups(P>0.05).The full-term pregnancy rate of the study group was 92.86%,which was higher than 76.19%of the control group,and the difference was statistically signifi

关 键 词：孕早期 先兆流产 低分子肝素钠 间苯三酚 性激素 妊娠结局 凝血功能 

分 类 号：R714[医药卫生—妇产科学]