马来酸麦角新碱联合卡贝缩宫素治疗宫缩乏力性产后出血患者的效果  

Effects of Ergometrine maleate combined with Carbetocin in treatment of patients with postpartum hemorrhage due to uterine inertia

作　　者：李素华 LI Suhua(Department of Obstetrics and Gynecology of Yucheng County People’s Hospital,Shangqiu 476300 Henan,China)

机构地区：[1]虞城县人民医院妇产科,河南商丘476300

出　　处：《中国民康医学》2025年第8期95-97,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察马来酸麦角新碱联合卡贝缩宫素治疗宫缩乏力性产后出血患者的效果。方法:回顾性分析2022年4月至2024年4月该院收治的85例宫缩乏力性产后出血患者的临床资料,根据治疗方法不同将其分为对照组(n=42)与观察组(n=43)。对照组采用卡贝缩宫素治疗,观察组在对照组基础上联合马来酸麦角新碱治疗。比较两组产后2、24 h出血量和止血时间,治疗前后凝血指标[纤维蛋白原(FIB)、凝血酶原时间(PT)、凝血酶时间(TT)]水平,以及不良反应发生率。结果:产后2、24 h,观察组出血量均少于对照组,止血时间短于对照组,差异有统计学意义(P<0.05);治疗后,两组FIB水平均高于治疗前,且观察组高于对照组,两组PT、TT均短于治疗前,且观察组短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:马来酸麦角新碱联合卡贝缩宫素治疗宫缩乏力性产后出血患者可改善凝血指标水平,减少出血量,缩短止血时间,效果优于单纯卡贝缩宫素治疗。Objective:To observe effects of Ergometrine maleate combined with Carbetocin in treatment of patients with postpartum hemorrhage due to uterine inertia.Methods:The clinical data of 85 patients with postpartum hemorrhage due to uterine inertia admitted to this hospital from April 2022 to April 2024 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=42)and observation group(n=43).The control group was treated with Carbetocin,while the observation group was treated with Ergometrine maleate on the basis of that of the control group.The amount of bleeding 2 and 24 h after delivery and the hemostasis time,the coagulation indexes[fibrinogen(FIB),prothrombin time(PT),thrombin time(TT)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:2 and 24 h after delivery,the amount of bleeding in the observation group was less than that in the control group,the hemostasis time was shorter than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the FIB levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the PT and TT in the two groups were shorter than those before treatment,and those in the observation group were shorter than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ergometrine maleate combined with Carbetocin in the treatment of the patients with postpartum hemorrhage due to uterine inertia can improve the levels of coagulation indexes,reduce the amount of bleeding,and shorten the hemostasis time.Moreover,it is superior to simple Carbetocin treatment.

关 键 词：宫缩乏力性产后出血 马来酸麦角新碱 卡贝缩宫素 不良反应 

分 类 号：R714.46[医药卫生—妇产科学]