定喘汤联合布地奈德福莫特罗治疗慢性阻塞性肺疾病急性加重期患者的效果  

Effects of Dingchuan decoction combined with Budesonide and Formoterol in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：韩万利 HAN Wanli(Department of Lung,Liver,Gallbladder,Spleen and Stomach of Yuzhou Hospital of Traditional Chinese Medicine,Xuchang 461670 Henan,China)

机构地区：[1]禹州中医院肺肝胆脾胃科,河南许昌461670

出　　处：《中国民康医学》2025年第8期109-111,115,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察定喘汤联合布地奈德福莫特罗治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的效果。方法:选取2020年9月至2023年10月该院收治的80例AECOPD患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各40例。对照组予以布地奈德福莫特罗治疗,研究组在对照组基础上联合定喘汤治疗。比较两组临床疗效,治疗前后中医证候积分、肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)]水平、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平,以及不良反应发生率。结果:研究组治疗总有效率为95.00%(38/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗后,两组发热咳嗽、喘促痰鸣、胸膈满闷、胸胁胀痛等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组FEV_(1)、FVC水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:定喘汤联合布地奈德福莫特罗治疗AECOPD患者可提高治疗总有效率和肺功能指标水平,降低中医证候积分和炎性因子水平,效果优于单纯布地奈德福莫特罗治疗。Objective:To observe effects of Dingchuan decoction combined with Budesonide and Formoterol in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A prospective study was conducted on 80 patients with AECOPD admitted to the hospital from September 2020 to October 2023.According to the random number table method,they were divided into study group and control group,40 cases in each group.The control group was treated with Budesonide and Formoterol,while the study group was treated with Dingchuan decoction on the basis of that of the control group.The clinical efficacy,the TCM syndrome scores,the lung function indexes[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)]levels and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.00%(38/40),which was higher than 80.00%(32/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as fever and cough,dyspnea and phlegm,chest and diaphragm fullness,chest and hypochondrium distending pain in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV_(1) and FVC in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6 and TNF-αin the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between th

关 键 词：定喘汤 布地奈德福莫特罗 慢性阻塞性肺疾病急性加重期 肺功能 炎性因子 中医证候积分 

分 类 号：R563[医药卫生—呼吸系统]