苏黄止咳胶囊联合孟鲁司特钠治疗咳嗽变异性哮喘患者的效果  

Effects of Suhuang Zhike capsules combined with Montelukast sodium in treatment of cough variant asthma

作　　者：梁玉坵 LIANG Yuqiu(Department of general medicine of Jindou Health Center of Yongchun County,Quanzhou 362600 Fujian,China)

机构地区：[1]永春县锦斗卫生院全科,福建泉州362600

出　　处：《中国民康医学》2025年第8期112-115,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察苏黄止咳胶囊联合孟鲁司特钠治疗咳嗽变异性哮喘(CVA)患者的效果。方法:回顾性分析2019年1月至2023年1月该院收治的60例CVA患者的临床资料,按照治疗方法不同将其分为对照组和观察组各30例。对照组给予孟鲁司特钠治疗,观察组在对照组基础上联合苏黄止咳胶囊治疗。比较两组临床疗效,治疗前后中医证候积分、肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)]水平、炎性因子[白细胞介素-6(IL-6)、白细胞介素-13(IL-13)、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率。结果:观察组治疗总有效率为90.00%(27/30),高于对照组的66.67%(20/30),差异有统计学意义(P<0.05);治疗后,两组咳嗽、咳痰不爽、头痛、恶风等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组FEV_(1)、FVC水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、IL-13、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:苏黄止咳胶囊联合孟鲁司特钠治疗CVA患者可提高治疗总有效率和肺功能指标水平,降低中医证候积分和炎性因子水平,效果优于单纯孟鲁司特钠治疗。Objective:To observe effects of Suhuang Zhike capsules combined with Montelukast sodium in treatment of patients with cough variant asthma(CVA).Methods:The clinical data of 60 patients with CVA admitted to the hospital from January 2019 to January 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,30 cases in each group.The control group was treated with Montelukast sodium,while the observation group was treated with Suhuang Zhike capsules on the basis of that of the control group.The clinical efficacies,the TCM syndrome scores,the levels of lung function indexes[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)]and inflammatory factors[interleukin-6(IL-6),interleukin-13(IL-13),tumor necrosis factor-α(TNF-α)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 90.00%(27/30),which was higher than 66.67%(20/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as cough,expectoration,headache and aversion to wind in the two groups were lower than those before treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV_(1) and FVC in the two groups were higher than those before treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,IL-13 and TNF-αin the two groups were lower than those before treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Suhuang Zhike c

关 键 词：苏黄止咳胶囊 孟鲁司特钠 咳嗽变异性哮喘 肺功能 中医证候积分 炎性因子 

分 类 号：R562.25[医药卫生—呼吸系统]