黄龙止咳颗粒联合孟鲁司特钠治疗急性支气管炎患儿的效果  

Effects of Huanglong Zhike granules combined with Montelukast sodium in treatment of children with acute bronchitis

作　　者：赵宇欣 马春英[1] ZHAO Yuxin;MA Chunying(Department of General Pediatrics of Sanmenxia Central Hospital,Sanmenxia 472099 Henan,China)

机构地区：[1]三门峡市中心医院普通儿科,河南三门峡472099

出　　处：《中国民康医学》2025年第8期116-118,122,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察黄龙止咳颗粒联合孟鲁司特钠治疗急性支气管炎患儿的效果。方法:选取2021年11月至2023年12月该院收治的154例急性支气管炎患儿进行前瞻性研究,按照随机数字表法将其分为对照组与研究组各77例。对照组采用孟鲁司特钠治疗,研究组在对照组基础上联合黄龙止咳颗粒治疗。比较两组临床症状(鼻塞流涕、咳嗽、喘息、咳痰)消失时间,治疗前后肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、最大呼气流量(PEF)]水平、免疫球蛋白(Ig)指标(Ig A、Ig G、Ig M)水平、炎性因子[降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、白细胞介素-17(IL-17)]水平和不良反应发生率。结果:研究组鼻塞流涕、咳嗽、喘息、咳痰等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组FEV_(1)、FVC、PEF水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组Ig A、Ig G、Ig M水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组PCT、TNF-α、IL-4、IL-17水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:黄龙止咳颗粒联合孟鲁司特钠治疗急性支气管炎患儿可提高肺功能指标和Ig指标水平,缩短临床症状消失时间,以及降低炎性因子水平的效果优于单纯孟鲁司特钠治疗。Objective:To observe effects of Huanglong Zhike granules combined with Montelukast sodium in treatment of children with acute bronchitis.Methods:A prospective study was conducted on 154 children with acute bronchitis admitted to the hospital from November 2021 to December 2023.According to the random number table method,they were divided into control group and study group,77 cases in each group.The control group was treated with Montelukast sodium,while the study group was treated with Huanglong Zhike granules on the basis of that of the control group.The disappearance time of clinical symptoms(nasal congestion and runny nose,cough,wheezing,expectoration),the levels of pulmonary function indexes[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),peak expiratory flow(PEF)],immunoglobulin(Ig)indexes IgA,IgG,IgM)and inflammatory factors[procalcitonin(PCT),tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),interleukin-17(IL-17)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The disappearance time of clinical symptoms such as nasal congestion,runny nose,cough,wheezing and expectoration in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV_(1),FVC and PEF in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IgA,IgG and IgM in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PCT,TNF-α,IL-4 and IL-17 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).H

关 键 词：急性支气管炎 黄龙止咳颗粒 孟鲁司特钠 炎性因子 肺功能 免疫球蛋白 

分 类 号：R725.6[医药卫生—儿科]