清热宣痹汤联合穴位贴敷治疗急性鼻窦炎患儿的效果  

Effects of Qingre Xuanbi decoction combined with acupoint application in treatment of children with acute nasosinusitis

作　　者：欧阳俊辉[1] 黄甡[1] 李付根[1] 井小进 OUYANG Junhui;HUANG Shen;LI Fugen;JING Xiaojin(Department of Pediatrics of the First Affiliated Hospital of Henan University of Chinese Medicine,Henan Children’s Hospital of Integrated Traditional Chinese and Western Medicine,Henan Rehabilitation Hospital of Integrated Traditional Chinese and Western Medicine,Zhengzhou 450000 Henan,China)

机构地区：[1]河南中医药大学第一附属医院、河南中西医结合儿童医院、河南省中西医结合康复医院儿科,河南郑州450000

出　　处：《中国民康医学》2025年第8期126-129,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察清热宣痹汤联合穴位贴敷治疗急性鼻窦炎(ARS)患儿的效果。方法:选取2021年12月至2023年12月河南中医药大学第一附属医院收治的78例ARS患儿进行前瞻性研究,按照随机数字表法将其分为对照组与观察组各39例。对照组采用穴位贴敷治疗,观察组在对照组基础上联合清热宣痹汤治疗。比较两组临床疗效,治疗前后临床症状(发热、鼻塞、流涕、嗅觉减退)评分、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、T细胞亚群指标(CD3^(+)、CD4^(+))水平、鼻腔状况(Lund-Kennedy评分法)评分、鼻黏膜纤毛输送率(MTR)水平、鼻黏膜纤毛清除率(MCC)水平,以及不良反应发生率。结果:观察组治疗总有效率为94.87%(37/39),高于对照组的76.92%(30/39),差异有统计学意义(P<0.05);治疗后,两组发热、鼻塞、流涕、嗅觉减退等临床症状评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、IL-6水平均低于治疗前,且观察组低于对照组,两组CD3^(+)、CD4^(+)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组Lund-Kennedy评分均低于治疗前,且观察组低于对照组,两组MCC、MTR水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:清热宣痹汤联合穴位贴敷治疗ARS患儿可提高治疗总有效率、T细胞亚群指标水平、MCC水平和MTR水平,以及降低临床症状评分、炎性因子水平和鼻腔状况评分,效果优于单纯穴位贴敷治疗。Objective:To observe effects of Qingre Xuanbi decoction combined with acupoint application in treatment of children with acute nasosinusitis(ARS).Methods:A prospective study was conducted on 78 children with ARS admitted to the First Affiliated Hospital of Henan University of Chinese Medicine from December 2021 to December 2023.According to the random number table method,they were divided into control group and observation group,39 cases in each group.The control group was treated with acupoint application,while the observation group was treated with Qingre Xuanbi decoction on the basis of that of the control group.The clinical efficacy,the clinical symptoms(fever,nasal congestion,runny nose,hyposmia)scores,the inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]levels,the T cell subsets(CD3^(+),CD4^(+))levels,the nasal cavity status(Lund-Kennedy score)scores,the nasal mucociliary transport rate(MTR)levels,the nasal mucociliary clearance rate(MCC)levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.87%(37/39),which was higher than 76.92%(30/39)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of clinical symptoms such as fever,nasal congestion,runny nose and hyposmia in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-αand IL-6 in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of CD3^(+)and CD4^(+)in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the Lund-Kennedy scor

关 键 词：儿童 急性鼻窦炎 清热宣痹汤 穴位贴敷 炎性因子 T细胞亚群 Lund-Kennedy评分 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]