早期NT超声检查联合孕中期彩色多普勒超声检查在胎儿畸形筛查中的诊断效能  

Diagnostic efficiency of early NT ultrasonography combined with mid-pregnancy color Doppler ultrasonography in second trimester of pregnancy in screening of fetal malformations

作　　者：魏彦雯 王佳[1] WEI Yanwen;WANG Jia(Department of Ultrasound Diagnosis of Women&Infants Hospital of Zhengzhou,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州市妇幼保健院超声诊断科,河南郑州450000

出　　处：《中国民康医学》2025年第8期130-133,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨早期颈项透明层厚度(NT)超声检查联合孕中期彩色多普勒超声(简称彩超)检查在胎儿畸形筛查中的诊断效能。方法:选取2022年5月至2023年12月于该院就诊的98例疑似胎儿畸形孕妇进行前瞻性研究,所有孕妇均行早期NT超声检查,并于孕20~27周时行彩超检查,比较早期NT超声、孕中期彩超单项及联合检查在胎儿畸形筛查中的诊断效能,及对不同胎儿畸形类型的检出率。结果:以引产/分娩结果为金标准,结果显示,98例疑似胎儿畸形孕妇中阳性23例,包括心血管异常8例,四肢发育异常6例,无脑儿及全前脑各2例,脑积水及巨膀胱各1例,其他3例;阴性75例;早期NT超声检查诊断阳性22例,阴性76例;彩超检查诊断阳性24例,阴性74例;联合检查诊断阳性31例,阴性67例。早期NT超声检查联合彩超检查诊断胎儿畸形的灵敏度均高于二者单项检查,漏诊率均低于二者单项检查,差异有统计学意义(P<0.05);联合检查对不同胎儿畸形类型的检出率高于二者单项检查,差异有统计学意义(P<0.05)。结论:早期NT超声检查联合孕中期彩超检查在胎儿畸形筛查中的诊断效能高于二者单项检查。Objective:To investigate diagnostic efficiency of early nuchal translucency thickness(NT)ultrasonography combined with mid-pregnancy color Doppler ultrasonography in screening of fetal malformations.Methods:A prospective study was conducted on 98 pregnant women with suspected fetal malformations who were treated in this hospital from May 2022 to December 2023.All pregnant women underwent early NT ultrasound examination and color Doppler ultrasound examination at 20-27 weeks of gestation.The diagnostic efficiency of single and combined examinations of early NT ultrasound and mid-pregnancy color Doppler ultrasound in the fetal malformation screening,and the detection rates of different fetal malformation types were compared.Results:The gold standard of induced labor/delivery showed that among the 98 pregnant women with suspected fetal malformations,23 cases were diagnosed as positive,including 8 cases of cardiovascular abnormalities,6 cases of limb dysplasia,2 cases of anencephalus and 2 cases of holoprosencephaly,1 case of hydrocephalus and megabladder,and 3 cases of the other;and 75 cases were negative.Early NT ultrasound examination result showed that there were 22 cases were diagnosed as positive and 76 cases as negative;24 cases were diagnosed as positive and 74 cases were negative by color Doppler ultrasound examination;31 cases were diagnosed as positive and 67 cases were negative by combined examination.The sensitivity of early NT ultrasonography combined with color Doppler ultrasonography in the diagnosis of fetal malformation was higher than that of the two single examinations,the missed diagnosis rate was lower than that of the two single examinations,and the differences were statistically significant(P<0.05).The detection rate of combined examination for different types of fetal malformations was higher than that of two single examinations,and the differences were statistically significant(P<0.05).Conclusions:The diagnostic efficiency of early NT ultrasonography combined with mid-pregnancy color Doppler

关 键 词：早期颈项透明层厚度超声检查 彩色多普勒超声检查 孕中期 胎儿畸形 检查 诊断 效能 

分 类 号：R714.55[医药卫生—妇产科学]