帕拉米韦与磷酸奥司他韦治疗流行性感冒患儿的效果比较  

Comparison of effects of Peramivir and Oseltamivir phosphate in treatment of children with influenza

作　　者：于泉泉 YU Quanquan(Department of Pediatrics of Third People’s Hospital of Puyang,Puyang 457000 Henan,China)

机构地区：[1]濮阳市第三人民医院儿科,河南濮阳457000

出　　处：《中国民康医学》2025年第8期143-145,149,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较帕拉米韦与磷酸奥司他韦治疗流行性感冒患儿的效果。方法:选取2021年1月至2024年1月该院收治的80例流行性感冒患儿进行前瞻性研究,按照随机数字表法将其分为对照组与观察组各40例。对照组采用磷酸奥司他韦治疗,观察组采用帕拉米韦治疗。比较两组临床疗效,临床症状(咳嗽、鼻塞、头痛、发热)消失时间,病毒转阴率,治疗前后免疫球蛋白(Ig)指标(IgM、IgG、IgA)水平、生命质量[儿童生活质量测定量表(PedsQL4.0)]评分,以及不良反应发生率。结果:观察组治疗总有效率为97.50%(39/40),高于对照组的77.50%(31/40),差异有统计学意义(P<0.05);观察组咳嗽、鼻塞、头痛、发热等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);观察组病毒转阴率为97.50%(39/40),高于对照组的77.50%(31/40),差异有统计学意义(P<0.05);治疗后,两组IgA、IgG、IgM水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组角色功能、生理功能、情感功能、社会功能等PedsQL4.0评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为5.00%(2/40),低于对照组的20.00%(8/40),差异有统计学意义(P<0.05)。结论:帕拉米韦治疗流行性感冒患儿可提高治疗总有效率、Ig指标水平、病毒转阴率和生命质量评分,缩短临床症状消失时间,以及降低不良反应发生率,效果优于磷酸奥司他韦治疗。Objective:To compare effects of Peramivir and Oseltamivir phosphate in treatment of children with influenza.Methods:A prospective study was conducted on 80 children with influenza admitted to the hospital from January 2021 to January 2024.According to the random number table method,they were divided into control group and observation group,40 cases in each group.The control group was treated with Oseltamivir phosphate,while the observation group was treated with Peramivir.The clinical efficacy,the disappearance time of clinical symptoms(cough,nasal congestion,headache,fever),the virus negative conversion rates,the immunoglobulin(Ig)index IgM,(IgG,IgA)levels,the quality of life[pediatric quality of life inventory(PedsQL4.0)]scores before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.50%(39/40),which was higher than 77.50%(31/40)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms such as cough,nasal congestion,headache and fever in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The virus negative conversion rate of the observation group was 97.50%(39/40),which was higher than 77.50%(31/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IgA,IgG and IgM in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the PedsQL4.0 scores for role function,physiological function,emotional function,and social function in both groups were higher than before treatment,and the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observa

关 键 词：流行性感冒 儿童 帕拉米韦 磷酸奥司他韦 免疫球蛋白 生命质量 病毒转阴率 

分 类 号：R511.7[医药卫生—内科学]