高通量与低通量血液透析在尿毒症患者中的应用效果比较  

Comparison of application effects of high-flux and low-flux hemodialysis in patients with uremia

作　　者：陈玲玲 CHEN Lingling(Department of Hemodialysis of Sinan County National Hospital of Traditional Chinese Medicine,Tongren 565100 Guizhou,China)

机构地区：[1]思南县民族中医院血液透析科,贵州铜仁565100

出　　处：《中国民康医学》2025年第8期146-149,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较高通量与低通量血液透析在尿毒症患者中的应用效果。方法:回顾性分析2023年3月至2024年2月该院收治的72例尿毒症患者的临床资料,根据治疗方法不同将其分为研究组与对照组各36例。研究组采用高通量血液透析,对照组采用低通量血液透析,比较两组临床疗效,治疗前后肾功能指标[β_(2)-微球蛋白(β_(2)-MG)、血尿素氮(BUN)、血肌酐(Scr)]水平、炎性因子[白细胞介素-6(IL-6)、单核细胞趋化蛋白-1(MCP-1)、超敏C反应蛋白(hs-CRP)]水平、钙磷代谢指标[血钙、血磷、甲状旁腺激素(PTH)]水平,以及并发症发生率。结果:研究组治疗总有效率为91.67%(33/36),高于对照组的72.22%(26/36),差异有统计学意义(P<0.05);治疗后,研究组β_(2)-MG、BUN、Scr水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组IL-6、MCP-1、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05);治疗后,两组血钙水平比较,差异无统计学意义(P>0.05);研究组血磷、PTH水平均低于对照组,差异有统计学意义(P<0.05);研究组并发症发生率为5.56%(2/36),低于对照组的25.00%(9/36),差异有统计学意义(P<0.05)。结论:高通量血液透析治疗尿毒症患者可提高治疗总有效率,降低肾功能指标、炎性因子、血磷和PTH水平,效果优于低通量血液透析治疗。Objective:To compare application effect of high-flux and low-flux hemodialysis in uremic patients.Methods:The clinical data of 72 patients with uremia admitted to this hospital from March 2023 to February 2024 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,36 cases in each group.The study group was treated with high-flux hemodialysis,while the control group was treated with low-flux hemodialysis.The clinical efficacy,the levels of renal function indexes[β_(2)-microglobulin(β_(2)-MG),blood urea nitrogen(BUN),serum creatinine(Scr)],inflammatory factors[interleukin-6(IL-6),monocyte chemoattractant protein-1(MCP-1),highsensitivity C-reactive protein(hs-CRP)]and calcium and phosphorus metabolism indexes[blood calcium,blood phosphorus,parathyroid hormone(PTH)]before and after the treatment,and the incidence of complications were compared between the two groups.Results:The total effective rate of the study group was 91.67%(33/36),which was higher than 72.22%(26/36)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels ofβ_(2)-MG,BUN and Scr in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,MCP-1 and hs-CRP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,there was no significant difference in the serum calcium level between the two groups(P>0.05).After the treatment,the levels of serum phosphorus and PTH in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of complications in the study group was 5.56%(2/36),which was lower than 25.00%(9/36)in the control group,and the difference was statistically significant(P<0.05).Conclusions:High-flux hemodialysis in the treatment of the uremic patients can improve the tota

关 键 词：尿毒症 高通量 低通量 血液透析 肾功能 炎性因子 血磷 血钙 

分 类 号：R692[医药卫生—泌尿科学]