分叉微血管内循环肿瘤细胞输运与黏附行为数值研究  

Transport and Adhesion Behavior of Circulating Tumor Cells in Bifurcated Microvessels:A Numerical Study

作　　者：张明哲 沈君[2] 刘振宇[1] ZHANG Mingzhe;SHEN Jun;LIU Zhenyu(School of Mechanical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China;Zhongshan Hospital Wusong Branch,Fudan University,Shanghai 200940,China)

机构地区：[1]上海交通大学机械与动力工程学院,上海200240 [2]复旦大学附属中山医院吴淞医院,上海200940

出　　处：《医用生物力学》2025年第2期449-455,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(52476081);上海市宝山区科委项目(2023-E-08)。

摘　　要：目的 分析循环肿瘤细胞(circulating tumor cells, CTCs)在分叉微血管中的运动、变形和黏附行为,揭示其在不同流场条件下的动力学行为,探究其在癌症转移过程中的作用规律。方法 采用细胞尺度建模方法,结合浸入边界-格子玻耳兹曼方法(immersed boundary-lattice Boltzmann method, IB-LBM)和黏附动力学模型,模拟CTC在微血管中的运动和黏附过程。结果 CTC的黏附行为明显受雷诺数(Re)和细胞表面弹性模量的影响。当Re=0.003时,CTC的黏附行为最为稳定;弹性模量较低的CTC在黏附过程中形变更为明显,并且表现出更强的黏附力。结论 CTC的力学特性和流场条件共同决定了其在微血管中的输运和黏附特性,Re和弹性模量的高低对CTC的变形和黏附起关键作用。研究结果对CTC的黏附特性进行机制解释,为癌症研究中的预防和治疗提供了新的潜在方向。Objective To analyze the motion,deformation,and adhesion behavior of circulating tumor cells(CTCs)in bifurcated microvessels,reveal their mechanical properties under different flow conditions and explore their role in the process of cancer metastasis.Methods A cell-scale modeling approach was adopted,combining the immersed boundary-lattice Boltzmann method(IB-LBM)and the adhesive-dynamics model to simulate the motion and adhesion behavior of circulating tumor cells in microvessels.Results The adhesion behavior of CTCs was significantly influenced by the Reynolds number(Re)and the surface elastic moduli of cells.Under the condition of Re=0.003,the adhesion behavior of CTCs was the most stable;CTCs with a lower surface elastic modulus exhibited greater deformation during adhesion and demonstrated stronger adhesive forces.Conclusions The mechanical properties of CTCs and flow field conditions jointly determine their transport and adhesion behavior in microvessels.The levels of Re and surface elastic modulus play a critical role in the deformation and adhesion of CTCs.The study of the adhesion characteristics of CTCs provides mechanistic insights and new potential directions for cancer prevention and treatment research.

关 键 词：循环肿瘤细胞 分叉微血管 细胞输运 细胞黏附 流固耦合 数值仿真 

分 类 号：R318.01[医药卫生—生物医学工程]