基于仿生物理模型的椭圆囊直线加速度生物力学响应  

Biomechanical Response of the Utricle to Linear Acceleration Based on a Bionic Physical Model

作　　者：龚俊杰[1] 项广成 姜亚妮 边义祥[1] GONG Junjie;XIANG Guangcheng;JIANG Yani;BIAN Yixiang(School of Mechanical Engineering,Yangzhou University,Yangzhou 225127,Jiangsu,China)

机构地区：[1]扬州大学机械工程学院,江苏扬州225127

出　　处：《医用生物力学》2025年第2期462-469,共8页Journal of Medical Biomechanics

摘　　要：目的 构建透明可视化的人体椭圆囊仿生模型,探究椭圆囊直线加速度的生物力学响应。方法 采用3D打印技术和PVA-明胶复合水凝胶制作方法,成功制备了与人体比例为10∶1的可视化椭圆囊物理模型。通过对该模型进行变加速和变方向刺激实验,探究椭圆囊囊斑的生物力学响应。结果 在1~5 Hz正弦往复直线激励下,仿生囊斑的响应振幅从4.11μm增长至48.82μm;仿生囊斑的响应振幅随着加速度的增加而线性增长。此外,囊斑还表现出对特定方向加速度的响应变形差异。结论 制备的仿生椭圆囊模型能够准确模拟人体椭圆囊的工作机制,有望为前庭功能障碍的病理研究提供新途径,并为仿生技术在生物医学工程领域的应用拓展新方向。Objective To construct a transparent and visualized bionic model of human utricle and explore the biomechanical response of the utricle to linear acceleration.Methods Using three-dimensioanl(3D)printing technology and PVA-gelatin composite hydrogel fabrication method,a visual physical model of the utricle with a ratio of 10∶1 to the human body was successfully prepared.The biomechanical response of the utricle macula was investigated by varying acceleration and direction stimulation experiments.Results Under 1-5 Hz sinusoidal reciprocating linear excitation,the response amplitude of the bionic macula increased from 4.11μm to 48.82μm.The response amplitude of the bionic macula increased linearly with the acceleration.In addition,the macula showed deformation differences in response to acceleration in a specific direction.Conclusions The bionic utricle model prepared in this study can accurately simulate the working mechanism of human utricle,which is expected to provide a new way for the pathological study of vestibular dysfunction and expand a new direction for the application of bionic technology in the field of biomedical engineering.

关 键 词：前庭系统 椭圆囊 囊斑 仿生模型 直线加速度 生物力学响应 

分 类 号：R318.01[医药卫生—生物医学工程]