3D打印干骺端骨修复支架的生物力学优化设计  

Biomechanically Optimized Design of Three-Dimensional-Printed Metaphysis Bone Repair Scaffolds

作　　者：武琦 李小康 汤臻 郑增辉 曹朋飞 徐峰[2] 郭征 WU Qi;LI Xiaokang;TANG Zhen;ZHENG Zenghui;CAO Pengfei;XU Feng;GUO Zheng(Department of Orthopedics,the Second Affiliated Hospital of Airforce Military Medical University,Xi’an 710038,China;Bioinspired Engineering and Biomechanics Center(BEBC),Xi’an Jiaotong University,Xi’an 710049,China)

机构地区：[1]空军军医大学第二附属医院骨科,西安710038 [2]西安交通大学仿生工程与生物力学研究所,西安710049

出　　处：《医用生物力学》2025年第2期477-484,共8页Journal of Medical Biomechanics

基　　金：“十四五”国家重点研发计划项目(2023YFC2412600);国家自然科学基金面上项目(82372124)。

摘　　要：恶性骨肿瘤手术切除常导致下肢长骨干骺端骨缺损。干骺端的形态异型性是传统治疗方法难以匹配目标缺损区域的原因。3D打印钛金属骨修复支架因其能够实现良好的外形匹配并提供足够的力学支撑,成为目前临床上有效的干骺端骨缺损治疗手段,然而现有常用骨支架难以精准匹配骨缺损部位生物力学环境,导致支架内部骨长入并不理想,术后假体松动断裂时有报道。骨作为一种高度力学敏感的器官,其命运受力学信号调节。因此,从生物力学角度出发进行骨支架设计以实现骨修复支架与骨缺损部位的力学适配,是影响骨缺损重建成败的关键因素。本文主要介绍干骺端骨缺损修复力学影响因素及与骨生物力学适配3D打印钛金属骨修复支架设计的研究进展,为骨支架的生物力学优化设计提供理论参考。Surgical intervention for malignant bone tumors frequently results in bone defects located at the metaphysis of the long bones in the lower extremities.The morphological heterogeneity of the metaphysis poses significant challenges for conventional treatment methods to adequately conform to the defect area.The utilization of three-dimensional(3D)-printed titanium bone repair scaffolds has emerged as an effective reconstructive approach for metaphyseal bone defects,as these scaffolds offer precise shape conformity and provide adequate mechanical support.However,the current commonly used scaffolds do not adequately replicate the biomechanical environment of bone defects,resulting in suboptimal bone ingrowth within the scaffolds and subsequent prosthesis loosening and failure post-operation.Bone is a highly force-responsive organ,and its fate is regulated by biomechanical signals.Consequently,designing scaffolds with consideration of biomechanical principles to ensure mechanical compatibility between the scaffolds and the bone defect sites is a critical factor influencing the success of bone defects reconstruction.This review primarily introduces the biomechanical factors influencing bone defect repair and the advancements in designing 3D-printed titanium bone repair scaffolds 477 biomechanically matched with bones,offering theoretical guidance for scaffold design and preparation.

关 键 词：骨生物力学 干骺端 骨修复 多孔支架 梯度设计 

分 类 号：R318.01[医药卫生—生物医学工程]