内皮细胞力学感受器在主动脉扩张疾病中的研究进展  

Research Progress of Endothelial Mechanoreceptors in Aortic Dilation Disease

作　　者：赵容 孙慧莹 李双双 陆清声 ZHAO Rong;SUN Huiying;LI Shuangshuang;LU Qingsheng(Department of Vascular Surgery,the First Affiliated Hospital of Naval Military Medical University,Shanghai 200240,China)

机构地区：[1]海军军医大学第一附属医院血管外科,上海200240

出　　处：《医用生物力学》2025年第2期492-498,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(82270510)。

摘　　要：主动脉腔内血流动力学复杂,其产生的机械力学刺激对主动脉扩张疾病的发生发展起关键作用。内皮细胞作为血管内膜的关键组成,通过力学感受器对血流引起的微环境变化做出精准响应。这些力学感受器包括离子通道、受体酪氨酸激酶和膜结构等,它们将机械应力转换为生化信号,从而影响血管的生理功能和病理变化。近年来,针对内皮细胞力学感受器在主动脉扩张疾病中的作用机制研究取得了显著进展。本文总结力学感受器介导内皮细胞功能调控主动脉扩张疾病的研究进展,并对未来的研究方向进行展望,以期为开发临床治疗策略提供新视角和新靶点。The hemodynamics within the aortic lumen is highly complex,and the mechanical stimuli generated by blood flow play a crucial role in the occurrence and progression of aortic dilation disease.Endothelial cells,as key components of the vascular endothelium,respond precisely to microenvironmental changes caused by blood flow through mechanoreceptors,including ion channels,receptor tyrosine kinases,and membrane structures.These mechanoreceptors convert mechanical stresses into biochemical signals,thereby affecting the physiological functions and pathological changes of blood vessels.In recent years,significant advances have been made in understanding the mechanisms by which endothelial mechanoreceptors are involved in aortic dilation diseases.This review summarizes the research progress of mechanoreceptor-mediated endothelial cell function in regulating aortic dilation diseases and provides a perspective on future research directions,with the aim of offering new insights and potential targets for the development of clinical treatment strategies.

关 键 词：主动脉扩张疾病 内皮细胞 力学感受器 血管生物力学 血流动力学 机械应力 

分 类 号：R318.01[医药卫生—生物医学工程]