清肺化痰汤内服结合中药外敷对小儿肺炎支原体肺炎风痰阻肺证的中医证候积分与肺功能水平的影响  

Effects on oral administration of Qingfei Huatan Decoction combined with external application of traditional Chinese medicine on the syndrome score and lung function level of children with mycoplasma pneumoniae pneumonia with wind phlegm obstruction syndrome

作　　者：李向云[1] 陈燕[1] 黄芳[1] 王鑫鑫 LI Xiangyun;CHEN Yan;HUANG Fang;WANG Xinxin(Zhengzhou People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州人民医院,郑州450003

出　　处：《天津中医药》2025年第5期568-572,共5页Tianjin Journal of Traditional Chinese Medicine

摘　　要：[目的]分析清肺化痰汤内服结合中药外敷对小儿肺炎支原体肺炎(MP)风痰阻肺证的中医证候积分与肺功能水平的影响。[方法]研究纳入2023年2月—2024年1月医院临床收治MP患儿78例为对象,数字抽签分组为对照组(39例)与研究组(39例),分别采用常规西药、清肺化痰汤内服+中药外敷治疗,均连续治疗10 d,比较组间中医证候积分、疗效、肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、75%、50%肺活量时呼气流量(FEF75、FEF50)]、炎症指标[C-反应蛋白(CRP)、中性粒细胞比例(NEU%)、淋巴细胞比例(LYM%)]、免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)水平及安全性。[结果]两组治疗前中医证候积分比较差异无统计学意义(P>0.05),治疗后组间比较,研究组中医证候积分更低(P<0.05);研究组MP患儿治疗有效率高于对照组(P<0.05);两组治疗前肺功能指标比较差异无统计学意义(P>0.05),治疗后组间肺功能指标比较,研究组肺功能指标(FVC、FEV1、FEF75、FEF50)高于对照组(P<0.05);治疗前组间炎症因子水平比较差异无统计学意义(P>0.05),治疗后组间比较,研究组CRP、NEU低于对照组,LYM高于对照组(P<0.05);治疗前组间Ig M、Ig A水平比较差异无统计学意义(P>0.05),治疗后组间免疫指标水平比较,研究组Ig M、Ig A高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。[结论]清肺化痰汤内服结合中药外敷疗效显著,能有效降低MP患儿中医证候积分、炎症水平,可有效促进患儿肺功能恢复,改善免疫球蛋白水平,且用药安全性高。[Objective]To analyze the effect of Qingfei Huatan Decoction combined with traditional Chinese medicine external application on the syndrome score and lung function level in mycoplasma pneumoniae pneumonia(MP)children with wind phlegm obstruction syndrome.[Methods]A study was conducted on 78 children with MP who were clinically admitted to hospitals from February 2023 to January 2024.They were randomly divided into control group(39 cases)and study group(39 cases)by digital drawing.They were treated with conventional Western medicine,Qingfei Huatan Decoction,and external application of traditional Chinese medicine for 10 consecutive days.The symptom scores,therapeutic effects,lung function[forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),expiratory flow rate at 75%and 50%vital capacity(FEF75,FEF50)],inflammatory indicators[C-reactive protein(CRP),neutrophil ratio(NEU%),and lymphocyte count],ratio(LYM%),immunoglobulin A(IgA),immunoglobulin M(IgM)levels,and safety were compared between the two groups.[Results]There was no statistically significant difference in the scores of primary and secondary symptoms between the two groups before treatment(P>0.05).After treatment,the scores of primary and secondary symptoms in the study group were lower than those in the control group(P<0.05);the treatment effectiveness rate of children with MP in the research group was higher than that in the control group(P<0.05).There was no statistically significant difference in lung function indicators between the two groups before treatment(P>0.05).After treatment,the study group had higher FVC,FEV1,FEF75,and FEF50 compared to the control group(P<0.05);before treatment,there was no statistically significant difference in the levels of inflammatory factors between the two groups(P>0.05).After treatment,the CRP and NEU of the study group were lower than those of the control group,while the LYM was higher than that of the control group(P<0.05);there was no statistically significant difference in the comparison o

关 键 词：清肺化痰汤 中药外敷 小儿肺炎支原体肺炎 风痰阻肺证 中医证候积分 肺功能 

分 类 号：R563.1[医药卫生—呼吸系统]